Dispersion of taste masked crystals or granules of active substances, chewable soft capsules filled with said dispersion, and process for preparing same
OwnerJulien Meissonnier, Fabrice Rose +1inventors
InventorsJulien Meissonnier, Fabrice Rose, Marie Bohn
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Abstract
The present invention concerns a dispersion of crystals or granules of active substance in a lipophilic vehicle, said crystals or granules being coated by a coating for taste masking purposes. The invention also it concerns unit dosage forms and preferentially chewable or fast dissolving soft gelatin capsules filled with said dispersion as well as process for manufacturing same.
Claims15
(iv) A dispersion of crystals or granules of active substance in a lipophilic vehicle, wherein said lipophilic vehicle has a solubilizing power for the active substance of less than 1.5 times the active substance concentration for which a taste is detected in water, and wherein said crystals or granules being coated by a coating for taste masking purposes.
(iv) A process for preparation of chewable soft capsules, comprising the steps of:
- a) preparing an outer envelope;
- b) as necessary preparing granules of active substance;
- c) coating the crystals of active substance or granules prepared above using a coating for taste masking purposes;
- d) as necessary dispersing additives in a lipophilic vehicle, wherein said lipophilic vehicle has a solubilizing power for the active substance of less than 1.5 times the active substance concentration for which a taste is detected in water, and optionally milling of this;
- e) dispersing the coated crystals or granules in the lipophilic vehicle;
- f) filling and sealing the capsules with said dispersion;
- g) drying the capsules.
Dependencies are inferred from the claim text.