Transdermal delivery system for dried particulate or lyophilized medications
AssigneeTransPharma Medical Ltd.
InventorsMeir Stern, Galit Levin
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Abstract
The present invention provides a system for transdermal delivery of dried or lyophilized pharmaceutical compositions and methods using thereof. The system comprises an apparatus for facilitating transdermal delivery of an agent that generates hydrophilic micro-channels, and a patch comprising a therapeutically active agent. The present invention is useful for transdermal delivery of hydrophilic agents, particularly of high molecular weight proteins.
Claims24
A system for transdermal delivery of a peptide or polypeptide from a dried pharmaceutical composition comprising:
- an apparatus for facilitating transdermal delivery of a peptide or polypeptide through skin of a subject, wherein the apparatus is capable of generating a plurality of micro-channels in an area on the skin of the subject, and a patch comprising a dried pharmaceutical composition comprising a peptide or polypeptide having up to two hundred amino acid residues.
A printed patch comprising a dried pharmaceutical composition comprising a peptide or polypeptide having up to two hundred amino acid residues.
A method for transdermal administration of a dried pharmaceutical composition comprising a peptide or polypeptide, the method comprising:
- (a) generating a plurality of micro-channels in an area of the skin of a subject;
- (b) affixing a printed patch to the area of the skin of the subject, the printed patch comprising a dried pharmaceutical composition comprising a therapeutically effective amount of peptide or polypeptide having up to two hundred amino acid residues;
- and
- (c) achieving dose efficiency of at least 10%.
Dependencies are inferred from the claim text.