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US 2006/0233857 A1Published application
Degradable elastomeric network
OwnerBrian Amsden, Gauri Misrainventors
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Abstract
One aspect of the invention provides a degradable/biocompatible elastomer. The elastomer comprises a degradable cross-linked network of a hydrophobic, hydrolysable amorphous star polymer and a hydrophilic, biocompatible polymer. The network may be crosslinked thermally or by irradiation. In a preferred embodiment, the elastomer is used for a drug delivery system, and is particularly useful for delivery of peptide and protein drugs.
Claims30
A degradable elastomer, comprising:
- a biocompatible degradable cross-linked network of:
- (i) a hydrophobic, hydrolysable amorphous star polymer;
- and
- (ii) a hydrophilic polymer;
- wherein one of the hydrophobic polymer or the hydrophilic polymer includes two or more cross-linkable groups on the polymer chain terminus, and the other of the hydrophobic polymer or the hydrophilic polymer includes one or more cross-linkable groups on the polymer chain terminus.
2 more elements
A method of preparing a biocompatible degradable elastomer, comprising:
- providing a hydrophobic, hydrolysable amorphous star polymer and a hydrophilic polymer, one of the hydrophobic polymer or the hydrophilic polymer including two or more cross-linkable groups on the polymer chain terminus, and the other of the hydrophobic polymer or the hydrophilic polymer including one or more cross-linkable groups on the polymer chain terminus;
- combining the hydrophobic, hydrolysable amorphous star polymer and the hydrophilic, biocompatible polymer;
- and
- cross-linking the hydrophobic, hydrolysable amorphous star polymer and the hydrophilic, biocompatible polymer to create a degradable cross-linked elastomer.
1 more element
Dependencies are inferred from the claim text.