Matrix composed of a naturally-occurring protein backbone cross linked by a synthetic polymer and methods of generating and using same
AssigneeRegentis Biomaterials Ltd.
InventorsDror Seliktar, Liora Almany
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Abstract
The present invention relates to biodegradable scaffolds composed of a naturally-occurring protein backbone cross-linked by a synthetic polymer. Specifically, the present invention provides PEGylated-fibrinogen scaffold and methods of generating and using same for treating disorders requiring tissue regeneration.
Claims57
A composition-of-matter comprising a naturally occurring protein or a bioactive fragment of said protein and at least two synthetic polymers covalently connected thereto, each of said at least two synthetic polymers having a functional group being capable of covalently attaching to a syntetic polymer of said at least two synthetic polymers so as to form a scaffold.
A scaffold comprising a plurality of protein molecules covalently attached therebetween so as to form the scaffold via a synthetic polymer having a first part and a second part covalently attached therebetween via a chemical moiety being chemically distinct from a repeating unit of said polymer.
A method of generating a scaffold comprising:
- (a) covalently attaching a naturally occurring protein or a bioactive fragment of said protein to at least two synthetic polymer through a first functional group, each of said at least two synthetic polymers having a second functional group to thereby obtain a polymer-protein precursor molecule;
- and subsequently
- (b) cross-linking a plurality of said precursor molecules to thereby generate the scaffold.
A composition-of-matter comprising a functional polyethylene glycol (PEG) attached to denatured fibrinogen or a bioactive fragment of said protein.
Dependencies are inferred from the claim text.