Implantable gel compositions and method of manufacture
OwnerKevin Brodbeck, Shamim Pushpala +1inventors
InventorsKevin Brodbeck, Shamim Pushpala, Steven Prestrelski
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Abstract
Methods and compositions for reducing the burst of beneficial agent from implantable systems is described. Such systems utilize compressed particulates of a beneficial agent, optionally mixed with a dissolution rate modulator or an agent exhibiting a characteristic of low solubility in water, such as a mixture of stearic acid and palmitic acid, dispersed throughout a bioerodible and biocompatible carrier.
Claims35
A composition comprising a carrier and particulates comprising a compressed mixture of an active agent and an agent exhibiting a characteristic of low solubility in water, the particulates being dispersed within the carrier.
A composition comprising:
- (a) a bioerodible gel comprising a polymer selected from the group consisting of polylactic acid, polyglycolic acid, and poly(lactide-co-glycolic) acid;
- (b) a solvent selected from the group consisting of an alkyl or aralkyl ester of benzoic acid;
- and (c) particulates dispersed within the gel, said particulates comprising a compressed mixture of an active agent and an agent exhibiting a characteristic of low solubility in water selected from the group consisting of pharmaceutically acceptable oils, fats, fatty acids, fatty acid esters, waxes, derivatives thereof, and mixtures of the foregoing.
A process for the preparation of an implantable composition comprising a bioerodible carrier having dispersed therein an active agent that comprises forming a compressed body of a mixture of the active agent and an agent exhibiting a characteristic of low solubility in water, crushing the body to form compressed particulates of the mixture of the active agent and the agent exhibiting a characteristic of low solubility in water, and dispersing the compressed particulates throughout the carrier.
Dependencies are inferred from the claim text.