Novel compounds
OwnerAlain Jacquetinventor
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Abstract
The present invention provides a novel treatment for allergy comprising the provision of a recombinant Der p 1/ProDer p 1/PreProDer p 1 allergen derivative, ProDer p 3 or a recombinant ProDer p 3/Der p 3/PreProDer p 3 allergen derivative with hypoallergenic activity. Pharmaceutical compositions comprising said mutant allergens which stimulate a Th1-type immune response in allergic or naïve individuals thereby reducing the potential for an allergic response upon contact with the wild-type allergen, are also provided.
Claims30
A recombinant Dermatophagoides pteronyssinus Der p 1 protein allergen derivative wherein said allergen derivative has a significantly reduced allergenic activity compared to that the wild-type allergen in which said derivative has been genetically mutated and in which the mutant comprises the three following mutations:
- a mutation of the cysteine 71 residue, a mutation of the cysteine 103 residue and a mutation of the cysteine 117 residue.
A recombinant Dermatophagoides pteronyssinus Der p 1 protein allergen derivative wherein said allergen derivative has a significantly reduced allergenic activity compared to that the wild-type allergen in which said derivative has been genetically mutated and in which the mutant comprises a deletion of amino acid residues 147 to 160 of Der p 1 or residues 227-140 of ProDer p 1.
A recombinant mutant allergen having any of the sequences selected from the group consisting of:, SEQ ID NO:
- 15, SEQ ID NO:
- 17.
A immunogenic composition as claimed herein for use in medicine.
A Dermatophagoides pteronyssinus ProDer p 3 or PreProDer p 3 protein allergen or derivative thereof, wherein said ProDer p 3, PreProDer p 3 or allergen derivative has a significantly reduced allergenic activity compared to Der p 3.
A recombinant allergen having the sequence of:
- SEQ ID NO:19.
An isolated nucleic acid molecule having the sequence of any of SEQ ID NOs.20 or 21.
A immunogenic composition as claimed herein for use in medicine.
Dependencies are inferred from the claim text.