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OwnerJavier Gomez, Rafael Calzada +6inventors
InventorsJavier Gomez, Rafael Calzada, Boris Luis Gonzalez, Edgar Diaz, Talena Yamile Perez, Anisia Silva Cabrera, Jorge Antonio Robles, Tomas Marcelino Hernandez
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A single oral administration dose medicinal preparation is derived from Vibrio cholerae vaccine strains which have a disrupted hemagglutinin protease gene and which are tagged with celA coding functions from Clostridium thermocellum are described. The strains are freeze-dried and derived from non toxigenic parented strains. The medicinal preparation includes lyopectrants. The single dose of 107 to 109 viable cells/single dose provides effective immunization, with antibacterial antibodies present in about 1 day to a peak activity in about 14 days.
A medicinal preparation suitable for oral administration to humans for inducing immunological protection against cholera comprising as essential ingredients:
A single oral administration dose medicinal preparation for immunological protection against cholera comprising:
13, The medicinal preparation of claim 5, wherein the lyoprotectants are commensurate with the strain.
The medicinal preparation of claim 13, said lyoprotectants comprise skim milk, sorbitol and peptone.
Dependencies are inferred from the claim text.