Composition for the prophylaxis and treatment of HBV infections and HBV-mediated diseases
AssigneeRhein Biotech Gesellschaft fur Neue Biotechnologische Prozesse und Produkte mbH
InventorKarl Melber
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Abstract
The present invention is a composition that comprises at least two hepatitis B virus surface antigens (HBsAgs), fragments thereof and/or nucleic acids encoding them, the HBsAgs differing in HBV genotype in the S region and/or pre-S1 region and the composition containing no HBV core antigen (HBcAg) or nucleic acid encoding that antigen. The present invention also includes pharmaceutical compositions, especially vaccines, comprising these compositions for the prevention and/or treatment of an HBV infection or an HBV-mediated disease. The present invention further includes a method of preparing a patient-specific medicament for the therapeutic treatment of hepatitis B.
Claims32
A composition comprising at least two hepatitis B virus surface antigens (HBsAgs), fragments thereof and/or nucleic acids encoding them, the HbsAgs each being present in the form of homogeneous particles and differing in hepatitis B virus (HBV) genotype in the S region and/or pre-S1 region of HbsAg, and the composition containing no HBV core antigen (HbcAg) or nucleic acid encoding that antigen.
A method of preparing a composition, comprising the step of mixing at least two hepatitis B virus surface antigens (HBsAgs), fragments thereof and/or nucleic acids encoding them, the HbsAgs differing in hepatitis B virus (HBV) genotype in the S region and/or preS1 region of HbsAg, and the composition containing no HBV core antigen (HbcAg) or nucleic acid encoding that antigen.
A method for the therapeutic or prophylactic treatment of an HBV infection or an HBV-mediated disease, comprising treating the HBV infection or the HBV-mediated disease with a composition comprising at least two hepatitis B virus surface antigens (HBsAgs), fragments thereof and/or nucleic acids encoding them, the HbsAgs differing in hepatitis B virus (HBV) genotype in the S region and/or preS1 region of HbsAg, and the composition containing no HBV core antigen (HbcAg) or nucleic acid encoding that antigen.
A method of preparing a medicament for the therapeutic treatment of hepatitis B, comprising the steps of:
- a) determining the HBV genotype with which a patient is infected;
- and
- b) providing a medicament comprising at least one HbsAg of an HBV genotype, a fragment thereof or a nucleic acid encoding HbsAg, the genotype thereof differing from the HBV genotype of the patient determined according to step (a).
Dependencies are inferred from the claim text.