Porin B (PorB) as a therapeutic target for prevention and treatment of infection by Chlamydia
AssigneeThe Regents of the University of California
InventorsRichard Stephens, Diane Kawa
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Abstract
The present invention features peptides of a PorB polypeptide, which PorB peptides are useful in production of antibodies that bind the full-length PorB polypeptide and as a therapeutic agent. In specific embodiments the invention features a composition comprising one or more PorB peptides (other than a full-length PorB polypeptide), which peptides contain at least one epitope that can elicit Chlamydia-neutralizing antibodies. The invention also features methods for induction of a protective immune response against infection by Chlamydia and Chlamydiophila.
Claims13
-32. (canceled)
An isolated nucleic acid comprising a nucleic acid sequence encoding a C. pneumoniae PorB polypeptide up to 60 amino acids in length wherein the polypeptide contains an amino acid sequence that is at least 67% identical to the amino acid sequence FTNLKFKVRKITSSHRGN (SEQ ID NO:
- 20), wherein the polypeptide binds to neutralizing C. trachomatis PorB polypeptide-specific anitsera;
- and.
An isolated nucleic acid comprising a nucleic acid sequence encoding a C. pneumoniae PorB polypeptide up to 60 amino acids in length having the amino acid sequence of FTNLKFKVRKITSSHRGN (SEQ ID NO:
- 20).
Dependencies are inferred from the claim text.