Use of plant oil-bodies in vaccine delivery systems
OwnerAnthony Schryvers, Wendy Hutchins +2inventors
InventorsAnthony Schryvers, Wendy Hutchins, Maurice Moloney, Joenel Alcantara
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Abstract
The present invention relates to the use of oil bodies as a vaccine adjuvant and delivery system for administration of vaccines by parenteral, mucosal (oral, nasal, pulmonary) and transdermal routes. In addition, the present invention relates to methods of eliciting an immune response in an animal by administering oil body-antigen complexes to said mammal. Finally, the present invention relates to methods of preparing oil body-antigen complexes.
Claims17
1-54. (canceled)
A method for the production of an oil body-antigen complex capable of eliciting an immune response in an animal comprising:
- a) isolating oil bodies;
- b) modifying said oil bodies to provide a means to attach an antigen;
- c) preparing an antigen with a linker that can attach to the modified oil bodies;
- d) coupling said antigen to the modified oil bodies to produce an oil body-antigen complex.
A method according to claim 83, wherein said oilseed plant is selected from a group consisting of plants from the genus Brassica, plants from the genus Linum, plants from the genus Glycine, plants from the genus Carthamus, and plants from the genus Arabidopsis.
Dependencies are inferred from the claim text.