Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
AssigneeImmunoGen, Inc.
InventorRavi Chari
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Abstract
The present invention is based on the discovery that the administration of at least one immunoconjugate and at least one chemotherapeutic agent provides an unexpectedly superior treatment for cancer. The present invention is directed to compositions comprising at least one immunoconjugate and at least one chemotherapeutic agent and to methods of treating cancer using at least one immunoconjugate and at least one chemotherapeutic agent. The present invention also provides methods of modulating the growth of selected cell populations, such as cancer cells, by administering a therapeutically effective amount of at least one chemotherapeutic agent and at least one immunoconjugate.
Claims32
A method of treating cancer in a patient in need thereof comprising administering to the patient a therapeutically effective amount of at least one chemotherapeutic agent and at least one immunoconjugate, wherein the immunoconjugate comprises at least one cell binding agent and at least one anti-mitotic agent.
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A method of modulating the growth of a selected cell population comprising administering to the selected cell population a therapeutically effective amount of at least one chemotherapeutic agent and at least one immunoconjugate, wherein the immunoconjugate comprises at least one cell binding agent and at least one anti-mitotic agent, wherein the selected cell population comprises cells selected from the group consisting of a cancer, an autoimmune disease, a graft rejection, a graft versus host disease, a viral infection, and a parasite infection.
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Dependencies are inferred from the claim text.