Use of il-18 inhibitors for treatment and/or prevention of peripheral vascular diseases
AssigneeMerck Serono SA
InventorsYolande Chvatchko, Alain Tedgui, Ziad Mallat
Life of this patent
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Abstract
The invention relates to the use of an inhibitor of IL-18 in the preparation of a medicament for treatment and/or prevention of peripheral vascular diseases. The invention further relates to the use of an IL-18 inhibitor for prevention of limb amputation.
Claims23
1-22. (canceled)
A method for the treatment and/or prevention of peripheral vascular disease in an individual in need thereof comprising administering to the individual an effective inhibiting amount of an IL-18 inhibitor and a pharmaceutically acceptable carrier.
A method for the treatment and/or prevention of claudication in an individual in need thereof comprising administering to the individual an effective inhibiting amount of an IL-18 inhibitor and a pharmaceutically acceptable carrier.
A method for the prevention and/or treatment of gangrene and/or ulcer in an individual in need thereof comprising administering to the individual an effective inhibiting amount of an IL-18 inhibitor and a pharmaceutically acceptable carrier.
A method for the prevention of limb amputation in an individual in need thereof comprising administering to the individual an effective inhibiting amount of an IL-18 inhibitor and a pharmaceutically acceptable carrier.
A method of treating and/or preventing peripheral vascular disease in an individual in need thereof comprising administering to the individual an expression vector comprising a coding sequence for an IL-18 inhibitor and a pharmaceutically acceptable carrier.
A method of treating and/or preventing peripheral vascular disease comprising administering to an individual a vector for inducing and/or enhancing the endogenous production of an inhibitor of IL-18 in a cell.
Dependencies are inferred from the claim text.