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US 2006/0233788 A1Published application
Anti-ghrelin antibodies
OwnerMark Heiman, Kristine Kikly +2inventors
InventorsMark Heiman, Kristine Kikly, Joseph Manetta, Derrick Witcher
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Abstract
Monoclonal antibodies, including humanized and chimeric antibodies, that bind acylated and unacylated human ghrelin are provided. Such monoclonal antibodies can be full-length, or an antigen-binding portion thereof, and are useful for neutralizing ghrelin activity, e.g., in a human subject suffering from a disorder in which ghrelin activity is detrimental.
Claims12
1-40. (canceled)
A monoclonal antibody or antigen-binding portion thereof, wherein:
- a) the light chain variable region comprises a peptide with the sequence shown in SEQ ID NO:3 and the heavy chain variable region comprises a peptide with the sequence shown in SEQ ID NO:12;
- b) the light chain variable region comprises a peptide with the sequence shown in SEQ ID NO:4 and the heavy chain variable region comprises a peptide with the sequence shown in SEQ ID NO:13;
- c) the light chain variable region comprises a peptide with the sequence shown in SEQ ID NO:30 and the heavy chain variable region comprises a peptide with the sequence shown in SEQ ID NO:32;
- or
- d) the light chain variable region comprises a peptide with the sequence shown in SEQ ID NO:31 and the heavy chain variable region comprises a peptide with the sequence shown in SEQ ID NO:33.
2 more elements
Dependencies are inferred from the claim text.