Human cd3-specific antibody with immunosuppressive properties
OwnerFabrice Le Gall, Sergey Kipriyanov +2inventors
InventorsFabrice Le Gall, Sergey Kipriyanov, Melvin Little, Uwe Reusch
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Abstract
Described are mono- and multivalent scFv-antibodies comprising the binding sites specific for human T cell marker CD3. These antibodies are strongly immunosuppressive and do not cause a significant release of cytokines. Furthermore, polynucleotides encoding said antibodies are described as well as vectors comprising said polynucleotides, host cells transformed therewith and their use in the production of said antibodies. Pharmaceutical compositions containing any of the above mentioned polynucleotides, antibodies or vectors are useful for immunotherapy, preferably against acute transplant rejections.
Claims17
A bivalent or multivalent antibody characterized by the following features:
- (a) it is capable of supressing an immune reaction;
- (b) it is devoid of constant antibody regions;
- and
- (c) it binds an epitope on the CD3 complex of the T-cell receptor.
Dependencies are inferred from the claim text.