Immunointeractive molecules and uses thereof
OwnerRobyn O'Hehirinventor
Life of this patent
Estimating the term…
Abstract
The present invention relates generally to molecules such as peptides, polypeptides and proteins which interact immunologically with T lymphocytes in subjects having latex allergy and genetic sequences encoding the same. These molecules are preferentially immunointeractive with T cells in subjects having a Hev b 6 allergy. The present invention also extends to antibodies, preferably monoclonal antibodies, directed to latex allergens and in particular to Hev b 6, and to the B cell epitopes recognized therein. The molecules of the present invention are useful in the development of diagnostic, therapeutic and prophylactic agents for conditions characterised by an aberrant, inappropriate or otherwise unwanted immune response to Hev b 6 or derivatives or homologues thereof.
Claims45
An isolated peptide comprising a Hev b 6 T cell epitope said peptide comprising at least 5 continuous amino acids of an amino acid sequence selected from the group consisting of:
- (i) amino acids 1-47;
- (ii) amino acids 55-83;
- (iii) amino acids 82-101;
- (iv) amino acids 136-155;
- inclusive, of Hev b 6 (e.g. SEQ ID NO:1);
- and wherein said peptide molecule is capable of interacting with T cells and modifying T cell function when incubated with cells from subjects having a condition characterized by an aberrant, unwanted or otherwise inappropriate immune response to Hev b 6.
(canceled)
(canceled)
(canceled)
15-28. (canceled)
An antibody directed to a Hev b 6 T cell epitope, said epitope being a peptide comprising at least 5 contiguous amino acids of an amino acid sequence selected from the group consisting of:
- (i) amino acids 1-47;
- (ii) amino acids 55-83;
- (iii) amino acids 82-101;
- (iv) amino acids 136-155;
- inclusive, of Hev b 6 (e.g. SEQ ID NO:
- 1);
- wherein said peptide molecule is capable of interacting with T cells and modifying T cell function when incubated with cells from subjects having a condition characterized by an aberrant, unwanted or otherwise inappropriate immune response to Hev b 6.
The hybridoma 1A5.4 (ECACC Accession No. 01122118) or 6E5.3.
34-37. (canceled)
An isolated nucleic acid sequence encoding or complementary to a sequence encoding a Hev b 6 T cell epitope, said epitope being a peptide comprising at least 5 contiguous amino acids of an amino acid sequence selected from the group consisting of:
- (i) amino acids 1-47;
- (ii) amino acids 55-83;
- (iii) amino acids 82-101;
- (iv) amino acids 136-155;
- inclusive, of Hev b 6 (e.g. SEQ ID NO:1);
- wherein said peptide molecule is capable of interacting with T cells and modifying T cell function when incubated with cells from subjects having a condition characterized by an aberrant, unwanted or otherwise inappropriate immune response to Hev b 6
43-46. (canceled)
Dependencies are inferred from the claim text.