C1-inh as a drug for treating viruses pathogenic to humans
OwnerNorbert Heimburger, Peter Gronskiinventors
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Abstract
The C1 esterase inhibitor (C1-INH) from human plasma is a sialic-acid-containing glycoprotein which can bind other glycoproteins and glycolipids which may be components or even membrane components of microoganisms of viral and bacterial origin. In accordance with the invention, this binding can inhibit the penetration of certain viruses into target cells.
Claims30
1-6. (canceled)
A method of treating an infection caused by at least one of a virus and a bacterium comprising administering to a subject an effective amount of a composition comprising C1 esterase inhibitor, wherein the at least one virus or bacterium comprises at least one of haemagglutinin and neuraminidase.
A method of modulating an immune response to a virus, to a bacterium, or to a vaccine against the virus or bacterium comprising administering to a subject a composition comprising C1 esterase inhibitor, wherein the virus or bacterium comprises at least one of haemagglutinin and neuraminidase.
A method of detecting the presence of a virus or a bacterium in a sample comprising:
- (a) obtaining a sample;
- (b) exposing the sample to C1-INH, wherein the C1-INH binds to the virus or bacterium;
- and
- (c) detecting the virus or bacterium bound to C1-INH
- wherein the virus or bacterium comprises at least one of haemagglutinin and neuraminidase.
A method of isolating a bacterium or virus comprising binding C1-INH to the virus or bacterium, wherein the virus or bacterium comprises at least one of haemagglutinin and neuraminidase.
A composition for the treatment of an infection caused by a virus or bacterium comprising C1-INH and antibodies against the virus or bacterium, wherein the virus or bacterium comprises at least one of haemagglutinin and neuraminidase.
Dependencies are inferred from the claim text.