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US 2006/0233764 A1Published application
Skin regeneration system
AssigneeQueensland University of Technology
InventorsZee Upton, Damien Harkin, David Leavesley
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Abstract
A cell culture medium and system are provided which eliminate or at least reduce the requirement for exogenous components such as serum and feeder cells. The cell culture medium comprises an IGF and vitronectin or fibronectin and, optionally an IGFBP, and is particularly suitable for propagating keratinocytes for subsequent use in skin growth and regeneration. This invention also relates to compositions and methods for skin growth and regeneration in situ, which utilize aerosol delivery of cultured keratinocytes.
Claims36
A mammalian cell culture medium comprising:
- (i) at least one IGF selected from IGF-I and IGF-II;
- (ii) vitronectin (VN) or a fragment thereof;
- and
- (iii) an absence of serum or an amount of serum which in the absence of said at least an IGF would not support cell growth.
1 more element
Dependencies are inferred from the claim text.