Materials and method of modulating the immune response
OwnerJim Xianginventor
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Abstract
Methods and materials to modulate the immune response to treat or prevent a disease, including methods of making T helper-antigen presenting cells and methods of using these cells. The invention also relates to methods of making exosome-absorbed dendritic cells and the uses of these cells to modulate the immune response to treat or prevent a disease.
Claims30
A method of making a T helper-antigen presenting cell comprising contacting an exosome derived from a dendritic cell with a CD4+ T cell under conditions that allow absorption of the exosome on the CD4+ T cell.
A method of making a T helper-antigen presenting cell comprising contacting a CD4+ T cell with an activated dendritic cell under conditions that allow for transfer of molecules from the dendritic cell to the CD4+ T cells.
A method of enhancing the immune response to treat or prevent a disease comprising administering an effective amount of a T helper-antigen presenting cell to an animal in need thereof.
A pharmaceutical composition for preventing or treating a disease comprising an effective amount of T helper-antigen presenting cells and a pharmaceutically acceptable carrier, diluent or excipient.
A method of making an exosome-absorbed dendritic cell comprising contacting an exosome derived from a first dendritic cell with a second dendritic cell under conditions that allow absorption of the exosome on the second dendritic cell.
A method of enhancing the immune response to treat or prevent a disease comprising administering an effective amount of an exosome-absorbed dendritic cell to an animal in need thereof.
A pharmaceutical composition for preventing or treating a disease comprising an effective amount of an exosome-absorbed dendritic cell and a pharmaceutically acceptable carrier, diluent or excipient.
Dependencies are inferred from the claim text.