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US 2006/0233745 A1Published application
Enclosures housing cell-coated supports for treating tumors
AssigneeThe Regents of the University of Michigan
InventorsRiley Rees, Jiyoun Kim, Daniel Remick, Belinda Adamson
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Abstract
The present invention relates to devices, systems and methods for treating tumors. In particular, the present invention relates to enclosures housing cell-coated supports for promoting regression of tumors, such as cancerous tumors, papillomas, and warts. In preferred embodiments, the present invention provides methods of promoting tumor regression employing enclosures secreting therapeutic proteins.
Claims23
A method for producing a cell-containing enclosure, comprising;
- a) providing,
- i) viable cells on solid support material,
- ii) a nucleic acid sequence encoding a therapeutic protein, wherein said therapeutic protein promotes tumor regression, and
- iii) an enclosure configured for housing said solid support material, wherein said enclosure comprises mesh material,
- b) transfecting said viable cells on said solid support material with said nucleic acid sequence, and
- c) placing said solid support material into said enclosure to produce a cell-containing enclosure capable of promoting tumor regression.
3 more elements
A method for promoting tumor regression, comprising;
- a) providing;
- i) viable cells on solid support material, wherein said viable cells secrete at least one therapeutic protein,
- ii) an enclosure housing said solid support material, wherein said enclosure comprises mesh material, and
- iii) a subject with a tumor,
- b) positioning said enclosure on said tumor of said subject such that regression of said tumor is promoted.
2 more elements
Dependencies are inferred from the claim text.