# US 2006/0233738 A1 · Composition for promoting production of type 1 collagen and/or elastin > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2006/0233738 A1 - Document ID: US20060233738A1 - Status: Published application - Kind: A1 - Application number: 10/550,224 - Filed: 2004-03-23 - Published: 2006-10-19 - Earliest claimed: 2003-03-25 - Inventors: Satoshi Miyata; Youko Handa; Tetsuhito Sakurai - Web page: https://patentgrep.com/patent/US20060233738A1 ## CPC - A23L 33/105: Plant extracts, their artificial duplicates or their derivatives - A61K 8/9789: Magnoliopsida [dicotyledons] - A61K 31/357: having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel - A61K 36/28: Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea - A61P 17/00: Drugs for dermatological disorders - A61P 17/16: Emollients or protectives, e.g. against radiation - A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 - A61Q 19/08: Anti-ageing preparations - A61K 2800/70: Biological properties of the composition as a whole - A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B) - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS ## Abstract This invention aims to provide a composition that promotes the production of type I collagen and/or elastin in the human skin fibroblast cells, wherein the composition improves the suppleness and elasticity of the skin, is amply effective in preventing and improving wrinkles and sagging, and is also very safe to the skin. The present invention relates to a composition that contains silymarin, which is a general term for flavonolignans such as silybin, silydianin, silychristin and isosilybin, wherein the aforementioned composition has a property to promote the production of type I collagen and/or property to promote the production of elastin. It also relates to a composition containing silymarin derived from a silymarin-containing plant and/or extract of such plant, wherein the aforementioned composition also has a property to promote the production of type I collagen and/or property to promote the production of elastin. ## Claims ### Claim 1 A composition characterized by containing silymarin and having a property to promote the production of type I collagen and/or a property to promote the production of elastin. ### Claim 2 (depends on 1) The composition as claimed in claim 1, wherein the silymarin is an extract from silymarin-containing plant and/or derived from silymarin-containing plant. ### Claim 3 (depends on 1) The composition as claimed in claim 1, which is used for preventing skin aging. ### Claim 4 (depends on 1) The composition as claimed in claim 1, which is used for external application on the skin. ### Claim 5 (depends on 1) The composition as claimed in claim 1, which is a food. ### Claim 6 (depends on 4) The composition as claimed in claim 4, which contains 0.7% to 2.0% of silymarin as an active ingredient. ### Claim 7 (depends on 1) The composition as claimed in claim 1, which is a cosmetic. ### Claim 8 (depends on 2) The composition as claimed in claim 2, which is used for preventing skin aging. ### Claim 9 (depends on 2) The composition as claimed in claim 2, which is used for external application on the skin. ### Claim 10 (depends on 3) The composition as claimed in claim 3, which is used for external application on the skin. ### Claim 11 (depends on 2) The composition as claimed in claim 2, which is a food. ### Claim 12 (depends on 3) The composition as claimed in claim 3, which is a food. ### Claim 13 (depends on 9) The composition as claimed in claim 9, which contains 0.7% to 2.0% of silymarin as an active ingredient. ### Claim 14 (depends on 10) The composition as claimed in claim 10, which contains 0.7% to 2.0% of silymarin as an active ingredient. ### Claim 15 (depends on 2) The composition as claimed in claim 2, which is a cosmetic. ### Claim 16 (depends on 3) The composition as claimed in claim 3, which is a cosmetic. ### Claim 17 A method for promoting the production elastin in an extracellular matrix of a dermis, comprising administrating to a subject in need thereof an effective amount of a composition comprising silymarin. ### Claim 18 (depends on 17) The method according to claim 17, wherein the administration is oral administration. ### Claim 19 (depends on 17) The method according to claim 17, wherein the administration is topical administration. ### Claim 20 (depends on 17) The method according to claim 17, wherein the administration is such that the production of elastin becomes double.