Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route

A composition for delivery of estazolam consisting of a condensation aerosol

• a) formed by volatilizing a thin layer of estazolam on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of estazolam and condensing the heated vapor of estazolam to form condensation aerosol particles,
• b) wherein said condensation aerosol particles are characterized by less than 5% estazolam degradation products, and
• c) the condensation aerosol has an MMAD of less than 3 microns.

A composition for delivery of midazolam consisting of a condensation aerosol

• a) formed by volatilizing a thin layer of midazolam on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of midazolam and condensing the heated vapor of midazolam to form condensation aerosol particles,
• b) wherein said condensation aerosol particles are characterized by less than 5% midazolam degradation products, and
• c) the condensation aerosol has an MMAD of less than 3 microns.

A composition for delivery of triazolam consisting of a condensation aerosol

• a) formed by volatilizing a thin layer of triazolam on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of triazolam and condensing the heated vapor of triazolam to form condensation aerosol particles,
• b) wherein said condensation aerosol particles are characterized by less than 5% triazolam degradation products, and
• c) the condensation aerosol has an MMAD of less than 3 microns.

A method of producing alprazolam in an aerosol form comprising:

• a. heating a thin layer of alprazolam on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the alprazolam to form a heated vapor of the alprazolam, and
• b. during said heating, passing air through the heated vapor to produce aerosol particles of the alprazolam comprising less than 5% alprazolam degradation products, and an aerosol having an MMAD of less than 3 microns.

A method of producing estazolam in an aerosol form comprising:

• a. heating a thin layer of estazolam on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the estazolam to form a heated vapor of the estazolam, and
• b. during said heating, passing air through the heated vapor to produce aerosol particles of the estazolam comprising less than 5% estazolam degradation products, and an aerosol having an MMAD of less than 3 microns.

A method of producing midazolam in an aerosol form comprising:

• a. heating a thin layer of midazolam on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the midazolam to form a heated vapor of the midazolam, and
• b. during said heating, passing air through the heated vapor to produce aerosol particles of the midazolam comprising less than 5% midazolam degradation products, and an aerosol having an MMAD of less than 3 microns.

A method of producing triazolam in an aerosol form comprising:

• a. heating a thin layer of triazolam on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the triazolam to form a heated vapor of the triazolam, and
• b. during said heating, passing air through the heated vapor to produce aerosol particles of the triazolam comprising less than 5% triazolam degradation products, and an aerosol having an MMAD of less than 3 microns.