Compositions for nasal administration of drug
AssigneeTranslational Research Ltd.
InventorsToshikazu Oki, Takashi Hanafusa, Shunji Haruta
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Abstract
Compositions for nasal administration, which comprise a pharmaceutical, a physiologically active peptide, or a peptide-related compound, and as the carrier thereof, crystalline cellulose with a specific particle diameter and/or partially pregelatinized starch are provided. Such compositions improve the in vivo absorption efficiency of pharmaceuticals.
Claims8
A granular composition for nasal administration, which comprises a powdered pharmaceutical and as a carrier thereof, a substantially water-insoluble polysaccharide powder, wherein the pharmaceutical is selected from physiologically active peptides with a molecular weight of 30,000 or less and peptide-related compounds, and wherein the water-insoluble polysaccharide is at least one selected from:
- a crystalline cellulose powder with 85 wt % or more of the particles distributed over a partial or the entire sieving particle diameter range of 20 to 60 μm;
- and a partially pregelatinized starch powder with a mean particle diameter of 20 to 100 μm, wherein the water-insoluble polysaccharide comprises at least the partially pregelatinized starch powder when the powdered pharmaceutical is an insulin.
Dependencies are inferred from the claim text.