Molecular resonant tunneling sensor and methods of fabricating and using the same
OwnerPhilip Barth, Carl Myerholtzinventors
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Abstract
Resonant tunneling devices and methods of using and fabricating the same are provided. The subject devices include a first and second fluid containment members separated by a fluid barrier having a single nanopore therein providing fluid communication between the first and second fluid containment members, wherein the nanopore has a top inner diameter that is smaller than a bottom inner diameter and includes first and second perimeter electrodes separated by an insulator element, and a proteinaceous channel positioned in the nanopore. Also provided are methods of fabricating such a device and methods of using such a device for improved detection and characterization of a sample.
Claims32
A nanopore device comprising:
- a first fluid containment member;
- a second fluid containment member;
- a fluid barrier separating said first and second fluid containment members;
- a nanopore present in said fluid barrier and comprising first and second perimeter electrodes separated by an insulator element;
- and
- a biopolymeric channel positioned in said nanopore.
A method for fabricating a nanopore in a solid substrate, comprising:
- (a) producing a nanodimensioned passageway through a planar solid substrate;
- (b) positioning an electrode element about an opening of said passageway, wherein said electrode element comprises first and second perimeter electrodes separated by an insulator element;
- and
- (c) positioning a channel in said nanodimensioned passageway;
- to produce said nanopore.
Dependencies are inferred from the claim text.