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US 2006/0231107 A1Published application
Antibody-targeted photodynamic therapy
OwnerRandolph Glickman, George Mayo +3inventors
InventorsRandolph Glickman, George Mayo, Stuart McKinnon, Robert Melendez, Neeru Kumar
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Abstract
Disclosed are photosensitizer-antibody conjugates and methods for making such conjugates. Also disclosed are methods for using photosensitizer-antibody conjugates in photodynamic therapy to treat subjects with various diseases.
Claims17
A method of treating a subject with ocular disease, comprising:
- a. administering to the subject a conjugate of a benzoporphyrin and an anti-VEGF antibody;
- and
- b. irradiating the subject with light, symptoms of the ocular disease being reduced as compared to a control lacking the conjugate.
A photosensitizer-antibody conjugate, comprising VISUDYNE linked bound to an anti-VEGF polyclonal antibody.
Dependencies are inferred from the claim text.