Method for generating antigen-presenting cells
OwnerRobinson Ramirez-Pineda, Heidrun Mollinventors
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Abstract
Described is a method for the generation of antigen-presenting cells (APC), preferably bone marrow-derived dendritic cells (BMDC) or peripheral blood-derived dendritic cells, as antigen carrier having immunostimulatory properties for anti-infective treatment comprising the steps of (a) pulsing the APC with antigen and (b) treating the APC with a CpG oligonucleotide. Said APC are useful as an immune prophylactic or immune therapeutic agent against diseases like AIDS, tuberculosis, malaria or leishmaniasis.
Claims15
A not naturally occurring dendritic cell (DC) having specific antigen presentation properties in an individual comprising a specific disease related antigen and a CpG molecule, wherein said DC derives from CD34+ bone marrow precursor cells or peripheral blood monocyte preparations.
A pharmaceutical kit comprising several packages, wherein a first package contains DC obtained from CD34+ bone marrow precursor cells or peripheral blood monocyte preparations by culturing the cells in IL-4 and GM-CSF, a second package with a CpG molecule and a third package with a disease related antigen.
Dependencies are inferred from the claim text.