Biocompatible polymeric vesicles self assembled from triblock copolymers
AssigneeUniversity of New Hampshire
InventorsJerome Claverie, Floraine Collette
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Abstract
Provided herein is a novel composition useful in assembling carrier vesicles for delivery of a biologically active agent to an animal. The composition comprises an amphiphilic triblock copolymer comprised entirely of biocompatible, biodegradable, and/or enzymatically degradable polymers. The composition is characterized by the ability to self assemble into an aqueous vesicle, thereby encapsulating an agent for delivery to the animal. Also provided is a method for making a composition for delivery of an agent and a method for administering the agent to an animal.
Claims47
A composition comprising a non-phospholipid containing amphiphilic triblock ABC copolymer wherein the A block is characterized as biocompatible, hydrophilic, and enzymatically degradable, wherein the B block is characterized as biocompatible, biodegradable and hydrophobic, and wherein the C block is characterized as biocompatible and hydrophilic, and further wherein the ABC triblock copolymer is characterized by the ability to self assemble into an aqueous vesicle.
An aqueous vesicle comprising a non-phospholipid containing amphiphilic triblock ABC copolymer wherein the A block is characterized as biocompatible, hydrophilic, and enzymatically degradable, wherein the B block is characterized as biocompatible, biodegradable and hydrophobic, and wherein the C block is characterized as biocompatible and hydrophilic, and further wherein the ABC triblock copolymer is characterized by the ability to self assemble into the aqueous vesicle, the vesicle further comprising an agent encapsulated in the aqueous vesicle.
A method for making a composition for delivery of an agent, the method comprising:
- a. providing a non-phospholipid containing amphiphilic triblock ABC copolymer wherein the A block is characterized as biocompatible, hydrophilic, and enzymatically degradable, wherein the B block is characterized as biocompatible, biodegradable and hydrophobic, and wherein the C block is characterized as biocompatible and hydrophilic, and further wherein the ABC triblock copolymer is characterized by the ability to self assemble into the aqueous vesicle;
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- b. contacting the non-phospholipid containing amphiphilic triblock ABC copolymer of step a) with an aqueous solution containing the agent to be delivered, effective to form an aqueous vesicle comprising the agent encapsulated in the vesicle comprising the non-phospholipid containing amphiphilic triblock ABC copolymer, thereby forming a composition for the delivery of the agent.
A method for administering an agent to an animal, the method comprising:
- a. providing a composition comprising
- i. a non-phospholipid containing amphiphilic triblock ABC copolymer wherein the A block is characterized as biocompatible, hydrophilic, and enzymatically degradable, wherein the B block is characterized as biocompatible, biodegradable and hydrophobic, and wherein the C block is characterized as biocompatible and hydrophilic, and further wherein the ABC triblock copolymer is characterized by the ability to self assemble into an aqueous vesicle;
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- ii. an agent to be delivered to an animal, the agent being characterized by the ability to be encapsulated in the aqueous vesicle of i);
- and
- b. administering the composition of step a) to an animal to which administration of the agent is desired.
Dependencies are inferred from the claim text.