Analysis of a skin reactivity and hypersensitivity

A method for non-invasive, in vivo determination of the conductivity of nerves in a region of skin, said method comprising:

• (a) providing a skin substrate to be analyzed;
• (b) applying a first non-invasive electrode to a measuring point of the skin substrate;
• (c) applying a second non-invasive electrode to a second point of the skin substrate;
• (d) subjecting the skin substrate to stimulation;
• and
• (e) analyzing a change in an electrical signal detected by the first and second non-invasive electrodes;
• wherein the first and second non-invasive electrodes are associated with an evaluation circuit for analyzing the electrical signal detected by the first and second non-invasive electrodes, the evaluation circuit comprising at least one amplifying element, at least one processing element, at least one recording element, and at least one microprocessor.

An apparatus for non-invasive, in vivo determination of the conductivity of nerves in a region of skin, said apparatus comprising:

• (a) at least one non-invasive measuring electrode suitable for detecting a signal representative of the electrical activity of (i) a sensory nerve of a skin substrate or of (ii) the brain;
• (b) an electronic stimulator connected to at least one stimulation electrode;
• (c) at least one reference electrode;
• (d) a circuit connected to the at least one non-invasive measuring electrode, the electronic stimulator, and the at least one reference electrode for evaluating signals detected or transmitted by said electrodes, the circuit comprising at least one amplifying element, at least one processing element, at least one recording element, and at least one microprocessor;
• such that a curve representative of change in the signal detected by the at least one non-invasive measuring electrode after a stimulation, as a function of time, can be created and displayed.