Process for preparing ursodeoxycholic acid di-sodium 3,7-disulfate
OwnerMassimo Ferrari, Matteo Bonaldi +1inventors
InventorsMassimo Ferrari, Matteo Bonaldi, Fabrizio Zinetti
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Abstract
Process for preparing ursodeoxycholic acid di-sodium 3,7-disulfate comprising: a) reacting ursodeoxycholic acid with sulfamic acid to give ursodeoxycholic acid di-ammonium 3,7-disulfate; b) treating ursodeoxycholic acid di-ammonium 3,7-disulfate with organic sodium bases or inorganic sodium bases and then treating the reaction mixture with an inorganic acid until a pH between 3.0 and 4.5 is reached to give ursodeoxycholic acid di-sodium 3,7-disulfate in solution; c) removing the salts present (by filtration) and then precipitating ursodeoxycholic acid di-sodium 3,7-disulfate by diluting with an organic solvent.
Claims25
1-28. (canceled)
Process for preparing ursodeoxycholic acid di-sodium 3,7-disulfate comprising:
- a) reacting ursodeoxycholic acid with sulfamic acid in dimethylformamide to give ursodeoxycholic acid di-ammonium 3,7-disulfate;
- b) treating the ursodeoxycholic acid di-ammonium 3,7-disulfate with organic sodium bases or inorganic sodium bases then treating the reaction mixture with an inorganic acid until a pH between 3.0 and 4.5 is reached to give ursodeoxycholic acid di-sodium 3,7-disulfate in solution.
Ursodeoxycholic acid di-ammonium 3,7-disulfate of formula:
Process for synthesizing ursodeoxycholic acid di-ammonium 3,7-disulfate comprising reacting ursodeoxycholic acid with sulfamic acid in N,N-dimethylformamide.
Dependencies are inferred from the claim text.