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US 2006/0224003 A1Published application
A process for the preparation of isosulphan blue
AssigneeInnovassynth Technologies (India) Ltd.
InventorsBALKRISHNA KULKARNI, SANKAR CHINNAKULANDAI, GIRISH KHANDEKAR, HAWALDAR MAURYA, ASHOK ARJUN, SANDEEP SOPE, SUMIT KAR
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Abstract
A process for the preparation of Isosulphan Blue is disclosed. The process comprises the following steps: Sulphonating orthochlorobenzaldehyde, treatment with sodium sulphite, basification, condensation and oxidation to obtain Isosulphan Blue.
Claims8
A process for the preparation of Isosulphan Blue, said process comprising the following steps:
- (a) sulphonating orthochlorobenzaldehyde with a sulphonating agent to obtain 4-chloro-3-formyl sulphonic acid;
- (b) treating 4-chloro-3-formyl sulphonic acid with sodium sulphite and subsequent basification thereof to obtain 1-formyl benzene-2,5-sulphonic acid disodium salt;
- (c) condensation of 1-formyl benzene-2,5-sulphonic acid disodium salt with N,N-diethylaniline using Hydrchloric acid to obtain a 4-[Bis[4-(diethylamino)phenyl]methyl]benzene-2,5-disulphonic acid disodium salt;
- (d) oxidation of 4-[Bis[4-(diethylamino)phenyl]methyl]benzene-2,5-disulphonic acid with an oxidizing agent, using an acid and a solvent, to obtain Isosulphan Blue.
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Dependencies are inferred from the claim text.