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US 2006/0223998 A1Published application
Synthetic LSD metabolite for preparing haptens used in an LSD metabolite immunoassay
OwnerFang-Jie Zhang, Hshiou-ting Liuinventors
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Abstract
A general method for the synthesis of OH-LSD and its analogs has been successfully developed. This method is convenient and efficient and allows preparation of a series of OH-LSD analogs with linkers attached at various (C-8, N-6 or N-1) positions.
Claims11
1-3. (canceled)
A method to prepare LSD-OH or an analog of LSD-OH comprising:
- (a) adding an aqueous solution of hydrobromic acid to LSD or an analogue of LSD in DMSO;
- (b) purifying the LSD-OH or analog of LSD-OH;
- and wherein the LSD analog is derivatized at position C-8, N-6 or N-1.
An intermediate for the preparation of immunogens to LSD or LSD-OH prepared by the process comprising:
- (a) providing an aqueous solution of hydrobromic acid, DMSO and LSD or an analogue of LSD derivatized at positions C-8, N-6 or N-1;
- and
- (b) purifying the LSD-OH or derivatized analog of LSD-OH.
Dependencies are inferred from the claim text.