US 2006/0223886 A1 · Derivatives of N-[heteroaryl(piperidine-2-yl) methyl]benzamide, preparation method thereof and application of same in therapeutics

Abstract

Compounds of formula (I) as defined herein: are useful for treating behavioral disorders associated with dementia, psychoses, in particular schizophrenia (deficient form and productive form) and acute or chronic extrapyramidal symptoms induced by neuroleptics; for the treatment of various forms of anxiety, panic attacks, phobias, and compulsive obsessive disorders; for treating various forms of depression, including psychotic depression; for treating disorders caused by alcohol abuse or weaning from alcohol, sexual behavior disorders, eating disorders and for treating migraine. Moreover, the compounds of the invention may be used for treating painful muscle contracture in rheumatology and in acute spinal pathology; for treating spastic contractures of medullary or cerebral origin; for the symptomatic treatment of acute and subacute pain of light to moderate intensity; for treating intense and/or chronic pain, neurogenic pain and intractable pain; for treating Parkinson's disease and Parkinson-like symptoms of neurodegenerative origin or induced by neuroleptics; for treating partial primary and secondary generalized epilepsy of simple or complex symptomology, mixed forms and other epileptic syndromes in addition to another antiepileptic treatment, or in monotherapy, for the treatment of sleep apnea, and for neuroprotection.

Claims5

Dependent claims

A compound of formula (I)

in which
R1 represents either a hydrogen atom, or a linear or branched (C1-C7)alkyl group optionally substituted with one or more fluorine atoms, or a (C3-C7)cycloalkyl group, or a (C3-C7)cycloalkyl(C1-C3)alkyl group, or a phenyl(C1-C3)alkyl group optionally substituted with one or two methoxy groups, or a (C2-C4)alkenyl group, or a (C2-C4)alkynyl group;
R2 represents a pyridyl, furyl, thienyl, thiazolyl or oxazolyl group, this group being optionally substituted with one or more substituents chosen from halogen atoms and trifluoromethyl and linear or branched (C1-C6)alkyl and (C1-C6)alkoxy groups;
R3 represents either a hydrogen atom, or one or more substituents chosen from halogen atoms and trifluoromethyl, linear or branched (C1-C6)alkyl, (C3-C7)cycloalkyl, (C1-C6)alkoxy, phenyl, cyano, acetyl, benzoyl, (C1-C6)thioalkyl, (C1-C6)alkylsulfonyl, carboxyl or (C1-C6)alkoxycarbonyl groups, or a group of general formula NR4R5 or SO2NR4R5 or CONR4R5 in which R4 and R5 each independently represent a hydrogen atom or a linear or branched (C1-C6)alkyl or (C3-C-7)cycloalkyl group, or R4 and R5 form, with the nitrogen atom that bears them, a pyrrolidine, piperidine or morpholine ring;
in the form of free base or of acid-addition salt, hydrate or solvate.

2 more elements

Dependencies are inferred from the claim text.

Derivatives of N-[heteroaryl(piperidine-2-yl) methyl]benzamide, preparation method thereof and application of same in therapeutics

Life of this patent

Derivatives of N-[heteroaryl(piperidine-2-yl) methyl]benzamide, preparation method thereof and application of same in therapeutics

Life of this patent

Abstract

Claims5