Methods of treatment utilizing certain melatonin derivatives
OwnerFrank Zemlaninventor
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Abstract
A method for treating anxiety disorders, affective disorders, intracranial injury, spinal cord injury, neurodegenerative diseases, sclerosis, migraine, fibromyalgia and cerebrovascular disease, using melatonin derivatives is disclosed. A specific melatonin derivative for use in the disclosed process is 13-methyl-6-chloromelatonin (otherwise referred to as (R)-N-[2-(6-chloro-5-methoxy-1H-indol-3-yl)propyl]acetamide).
Claims14
A method of treating a patient having a condition selected from anxiety disorders, affective disorders, obesity, intracranial injury, spinal cord injury, neurodegenerative disorders, sclerosis, migraines, fibromyalgia and cerebrovascular disease, comprising the administration to said patient of a safe and effective amount of a melatonin derivative selected from compounds having the formula
- wherein
- R1 is hydrogen, C1-C4 alkyl or C1-C4 alkoxy;
- R2 is hydrogen or C1-C4 alkyl;
- R3 is hydrogen, C1-C4 alkyl, phenyl or substituted phenyl;
- R4 is hydrogen, haloacetyl, C1-C5 alkanoyl, benzoyl or benzoyl substituted with halo or methyl;
- R5 and R6 are each individually hydrogen or halo;
- and
- R7 is hydrogen or C1-C4 alkyl;
- provided that when R3, R4 and R5 are each hydrogen, then R2 must be C1-C4 alkyl.
Dependencies are inferred from the claim text.