Indoloquinone Tumor Radiation Sensitization
OwnerRandy Burd, Luigi Lenaz +3inventors
InventorsRandy Burd, Luigi Lenaz, Shanta Chawla, Guru Reddy, Adam Dicker
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Abstract
This invention generally relates to Indoloquinone caused tumor radiation therapy sensitization. More specifically, this invention relates to the discovery of indoloquinones as a radiation sensitizer (radiation therapy adjuvant) due to its ability to selectively target hypoxic cells and to damage the DNA of these hypoxic cells. Indoloquinones do so with minimal normal cell and tissue toxicity.
Claims20
A method comprising sensitizing one or more tumors to radiation therapy by administering one or more indoloquinones.
A composition comprising one or more indoloquinones wherein said one or more indoloquinones are directed to be administered in conjunction with a radiation therapy for the treatment of a tumor.
A composition according to claim 13, wherein said one or more indoloquinones are directed to be administered in a manner selected from the group consisting of before all radiation therapies of said patient;
- before a subset of said radiation therapies of said patient;
- after all radiation therapies of said patient;
- after a subset of said radiation therapies of said patient;
- before and after all said radiation therapies of said patient;
- before all radiation therapies of said patient and after a subset of said radiation therapies of said patient;
- before a subset of said radiation therapies of said patient and after all radiation therapies of said patient;
- and before a subset of said radiation therapies of said patient and after a subset of said radiation therapies of said patient.
A dosing regimen comprising one or more indoloquinones and instructional information that directs the administration of said one or more indoloquinones in conjunction with a radiation therapy for the treatment of a tumor.
Dependencies are inferred from the claim text.