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US 2006/0223873 A1Published application
Isoxazole derivatives and methods of treating nitric oxide mediated diseases
AssigneeGeneblue Corporation
InventorsJiajiu Shaw, An-Rong Lee, Wen-Hsin Huang
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Abstract
A series of isoxazole derivatives and methods of suppressing, inhibiting, or preventing disorders mediated by nitric oxide (NO) and/or proinflammatory cytokines, such as TNF-α (tumor necrosis factor alpha), IL-1 (interlukin-1), and IL-6, are described.
Claims10
A compound of formula (I):
- or a physiological tolerable salt thereof,
- wherein R is
- wherein R1 is selected from the group consisting of ortho-OH, meta-OH, para-OH, ortho-OCH3, meta-OCH3, para-OCH3, ortho-O—CO—CH3, meta-O—CO—CH3, para-O—CO—CH3, ortho-NO2, meta-NO2, para-NO2, ortho-NH2, meta-NH2, para-NH2, ortho-NHCOCH3, meta-NHCOCH3, para-NHCOCH3,
- wherein R2 is lower alkyl or substituted lower alkyl.
1 more element
Dependencies are inferred from the claim text.