Thiophene-and thiazolesulfonamides as antineoplastic agents
AssigneeEli Lilly and Company
InventorsCora Grossman, Philip Hipskind, Ho-Shen Lin, Karen Lobb, Beatriz Lopez de Uralde Garmendia, Jose Lopez, Mary Mader, Michael Richett, Chuan Shih, Alfonso De Dios
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Abstract
The present invention provides antineoplastic compounds of the formula: and antineoplastic methods.
Claims7
1-17. (canceled)
A method of treating a susceptible neoplasm selected from the group consisting of metastatic soft tissue sarcoma, non-small cell lung cancer, melanoma, ovarian cancer, breast cancer, leukemia, lymphoma, renal cancer, prostate cancer, and multiple myeloma in a mammal comprising administering to a mammal in need of such treatment an oncolytically effective amount of a compound of Formula I:
- where:
- R1 is selected from the group consisting of halo, C1-C6 alkyl, and CF3;
- R2 is selected from the group consisting of halo, —NO2, C1-C6 alkyl, and CF3;
- R3′ is H, C1-C6 alkyl, C1-C4 alkoxy, C1-C6 alkylthio, or halo;
- R4′ is selected from the group consisting of H, halo, C1-C4 alkoxy, —COO(C1-C6 alkyl), C1-C6 alkyl optionally substituted with C1-C4 alkoxy, cyano, C1-C6 alkylthio, CF3, S-phenyl, and pyridinyl;
- R5 is halo, C1-C6 alkyl, or C1-C4 alkoxy;
- or
- a pharmaceutically acceptable base addition salt thereof.
Dependencies are inferred from the claim text.