Substituted 1,5-naphthyridine azolinones

A compound of the formula:

• wherein
• X is —S— or —NH—;
• R1 is selected from the group consisting of
• e) hydrogen,
• f) lower alkyl that optionally may be substituted by
• (1) aryl that optionally may be substituted by lower alkyl, OH, lower alkoxy, halogen, or perfluoro-lower alkyl,
• (2) heteroaromatic that optionally may be substituted by lower alkyl, ═O, and —NH, or
• (3) heterocyclo lower alkyl,
• g) cyclo lower alkyl that optionally may be substituted by aryl,
• h) lower alkoxy-lower alkyl,
• R2 is selected from the group consisting of
• f) cyano,
• g) hydrogen,
• h) CONR6R7,
• i) CO2R8, and
• j) lower alkyl optionally substituted by
• (1) OR9,
• (2) cyano, or
• (3) NR6R7;
• R3 selected from the group consisting of
• k) O-lower alkyl,
• l) S-lower alkyl,
• m) hydrogen,
• n) lower alkyl,
• o) cyclo lower alkyl,
• p) alkene,
• q) alkylene,
• r) NR6R7,
• s) COOR8, and
• t) CONR6R7,
• wherein, in each instance, lower alkyl, cyclo lower alkyl, lower alkene and lower alkylene may optionally be substituted by
• (4) OR9,
• (5) cyano, and
• (6) NR6R7,
• R4 is selected from the group consisting of
• f) hydrogen,
• g) lower alkyl,
• h) O-lower alkyl,
• i) cyclo lower alkyl containing from 3 to 6 carbon atoms, and
• is selected from (1) an aryl ring, (2) a heterocyclo lower alkyl ring and (3) heteroaromatic ring;
• R5 is selected from the group consisting of hydrogen and lower alkyl;
• R6 and R7 are each independently selected from the group consisting of
• d) hydrogen,
• e) lower alkyl which optionally may be substituted by
• (1) OR9,
• (2) halogen,
• (3) cyano, and
• (4) NR12NR13, and
• f) cyclo lower alkyl;
• R8 is selected from the group consisting of lower alkyl that optionally may be substituted by OR9, cyano or NR6R7;
• R9 is selected from the group consisting of
• c) hydrogen, and
• d) lower alkyl that optionally may be substituted by
• (1) OR12,
• (2) cyano, or
• (3) NR6R7;
• R10 and R11 are each independently selected from the group consisting of
• h) hydroxy,
• i) hydroxy-lower alkyl,
• j) hydrogen,
• k) lower alkyl,
• l) halogen,
• m) perfluro lower alkyl, and
• n) lower alkoxy;
• R12 and R13 are each independently selected from the group consisting of
• d) hydrogen,
• e) lower alkyl, and
• f) cyclo lower alkyl;
• and
• p is an integer from 0 to 6;
• or a pharmaceutically acceptable salt thereof.