Biaryl derived amide modulators of vanilloid VR1 receptor

A compound of Formula (I)

• wherein:
• A1 is phenyl, naphthalenyl, or thienyl;
• R1 is independently hydroxy;
• halogen;
• C1-8alkanyl optionally substituted with one or more substituents independently selected from the group consisting of halogen, fluorinated alkanyl and C1-8alkanyloxy;
• C1-8alkanyloxy optionally substituted with one or more substituents independently selected from the group consisting of halogen, fluorinated alkanyl, and C1-8alkanyloxy;
• fluorinated alkanyloxy;
• fluorinated alkanyl;
• C1-8alkanylthio optionally substituted with one or more substituents independently selected from the group consisting of halogen, fluorinated alkanyl and C1-8alkanyloxy;
• C3-8cycloalkanyl;
• C3-8cycloalkanyloxy;
• nitro;
• amino;
• C1-8alkanylamino;
• C1-8dialkanylamino;
• C3-8cycloalkanylamino;
• cyano;
• carboxy;
• C1-7alkanyloxycarbonyl;
• C1-7alkanylcarbonyloxy;
• C1-7alkanylaminocarbonyl;
• C1-7alkanylcarbonylamino;
• diC1-7alkanylaminocarbonyl;
• formyl;
• aminosulfonyl;
• C1-8alkanylaminosulfonyl;
• di(C1-8)alkanylaminosulfonyl;
• or cyano;
• p is 0, 1 or 2;
• L is C2-8alkandiyl, C2-8alkendiyl, or C2-8alkyndiyl and L is optionally substituted with a substituent selected from the group consisting of C1-8alkanyl, C3-8cycloalkanyl and phenyl optionally substituted with one to three substituents independently selected from the group consisting of C1-8alkanyl, C1-8alkanyloxy, halogen, hydroxy, fluorinated alkanyl, fluorinated alkanyloxy, amino, di(C1-3)alkanylamino, and C1-3alkanylamino;
• X is O or S;
• A2 is selected from the group consisting of phenyl, thien-2-yl, naphthalenyl, pyridinyl, pyrimidinyl, pyrazinyl, quinolinyl, and isoquinolinyl;
• R2 is independently selected from the group consisting of C1-8alkanyl, C1-8alkanyloxy, hydroxy(C1-8)alkanyl, fluorinated C1-8alkanyl, hydroxyl, halogen, carboxy, C1-8alkanyloxycarbonyl, and aminocarbonyl;
• q is 0, 1, or 2;
• A3 is selected from the group consisting of phenyl, thienyl, naphthalenyl, pyridinyl, pyrimidinyl, pyrazinyl, imidazolyl, oxazolyl, 4,5-dihydro-oxazolyl, pyrazolyl, dihydro-pyrazolyl, thiazolyl, thiadiazolyl, triazolyl, tetrazolyl, quinolinyl, isoquinolinyl, and indolyl;
• R3 is independently selected from the group consisting of hydroxy;
• halogen;
• C1-8alkanyl;
• hydroxy(C1-8)alkanyl;
• C1-8alkanyloxy optionally substituted with amino, C1-8alkanylamino, or C1-8dialkanylamino;
• fluorinated alkanyloxy;
• fluorinated alkanyl;
• C1-8alkanylthio;
• nitro;
• amino;
• C1-8alkanylamino;
• C1-8dialkanylamino;
• C3-8cycloalkanylamino;
• cyano;
• aminosulfonyl;
• carboxy;
• C1-8alkanylsulfonylamino;
• aminocarbonyl;
• C1-8alkanyloxycarbonyl;
• C1-4alkanyloxycarbonylamino;
• C1-8alkanylaminocarbonyl;
• C1-8alkanylcarbonylamino;
• diC1-8alkanylaminocarbonyl;
• oxo when A3 is dihydro-pyrazolyl;
• and formyl;
• and wherein the C1-8alkanyl group of any C1-8alkanylamino and C1-8dialkanylamino containing substituent of R3 is optionally substituted with hydroxy;
• r is 0, 1, or 2;
• R4 is hydrogen or C1-8alkyl;
• and enantiomers, diastereomers, tautomers, solvates, and pharmaceutically acceptable salts thereof.

A compound of Formula (I)

• wherein:
• A1 is phenyl, pyridinyl, or thienyl;
• R1 independently is C1-6alkanyl;
• fluorinated C1-6alkanyl;
• C1-8alkanylsulfonyl substituted with one to three fluoro substituents;
• C1-8alkanylthio substituted with one to three fluoro substituents;
• C1-8alkanylsulfinyl substituted with one to three fluoro substituents;
• chloro;
• fluoro;
• or N—C1-4alkanyl-N-cyclohexylamino;
• p is 1 or 2;
• L is C2-8alkandiyl, C2-8alkendiyl, or C2-8alkyndiyl and L is optionally substituted with a substituent selected from the group consisting of C1-4alkanyl, C3-8cycloalkanyl and phenyl;
• X is O or S;
• A2 is selected from the group consisting of phenyl, thienyl, pyridinyl, pyrimidinyl, pyrazinyl, quinolinyl, and isoquinolinyl;
• R2 is independently selected from the group consisting of C1-4alkanyl, hydroxy(C1-4)alkanyl, fluorinated C1-4alkanyl, and fluoro;
• q is 1 or 2;
• A3 is selected from the group consisting of phenyl, thienyl, pyridinyl, pyrimidinyl, and imidazolyl;
• R3 is independently selected from the group consisting of hydroxy, fluoro, chloro, C1-4alkanyl, hydroxy(C1-4)alkanyl, C1-4alkanyloxy optionally substituted with amino, C1-4alkanylamino, or C1-4dialkanylamino, fluorinated alkanyloxy, fluorinated alkanyl, amino, C1-4alkanylamino, C1-4dialkanylamino, C3-8cycloalkanylamino, cyano, aminosulfonyl, C1-4alkanylsulfonylamino, C1-4alkanyloxycarbonyl, C1-4alkanyloxycarbonylamino, aminocarbonyl, C1-4alkanylaminocarbonyl, C1-4alkanylcarbonylamino, diC1-4alkanylaminocarbonyl, and formyl, and wherein C1-4alkanyl in any of the foregoing C1-4alkanylamino and C1-4dialkanylamino containing substituent of R3 is optionally substituted with hydroxy;
• R4 is hydrogen or C1-4alkyl,
• provided that a compound of Formula 1 is other than
• a compound wherein p is 1, R1 is 4-trifluoromethylsulfonyl, A1 is phenyl, L is trans —CH═CH—, X is O, A2 is pyridin-3-yl, q is 1, R2 is 5-methyl, A3 is imidazol-1-yl, r is 2, R3 is 4,5-dichloro, and R4 is hydrogen;
• and
• enantiomers, diastereomers, tautomers, solvates, and pharmaceutically acceptable salts thereof.

A compound of Formula 1 wherein:

• A1 is phenyl, pyridinyl, or thienyl;
• R1 is independently C1-4alkanyl;
• fluorinated C1-4alkanyl;
• trifluoromethylsulfonyl;
• trifluoromethylthio;
• trifluoromethylsulfinyl;
• chloro;
• or N-methyl-N-cyclohexylamino;
• p is 1;
• L is C2-4alkandiyl or C2-4alkendiyl, and L is optionally substituted with a substituent selected from the group consisting of C1-4alkanyl, C3-8cycloalkanyl and phenyl;
• X is O;
• A2 is selected from the group consisting of phenyl, thienyl, pyridinyl, and isoquinolinyl;
• R2 is independently selected from the group consisting of methyl, hydroxymethyl, trifluoromethyl, and fluoro;
• q is 0, 1, or 2;
• A3 is 4-phenyl, 3-phenyl, 2-pyridin-4-yl, 2-pyridin-2-yl, 3-pyridin-4-yl, 2-pyridin-3-yl, 4-pyridin-4-yl, 4-pyridin-3-yl, 4-pyridin-2-yl, 4-pyrimidin-5-yl, 3-pyrimidin-2-yl or 4-imidazol-1-yl when A2 is phenyl;
• and when A2 is isoquinolin-5-yl, A3 is 8-pyridin-4-yl or 8-phenyl;
• and when A2 is pyridin-3-yl, A3 is 6-phenyl, 6-pyridin-3-yl, 6-pyridin-2-yl, 6-pyridin-4-yl, or 6-imidazol-1-yl;
• R3 is independently selected from the group consisting of hydroxy, fluoro, chloro, methyl, hydroxymethyl, C1-3alkanyloxy optionally substituted with amino, methylamino, or dimethylamino, trifluoromethoxy, trifluoromethyl, methylsulfonylamino, t-butoxycarbonylamino, aminocarbonyl, and methylcarbonylamino;
• r is 1;
• R4 is hydrogen, and
• enantiomers, diastereomers, tautomers, solvates, and pharmaceutically acceptable salts thereof.

A compound of Formula (I)

• wherein:
• A1 is phenyl or thienyl;
• R1 independently is C1-6alkanyl or fluorinated C1-6alkanyl;
• p is 1 or 2;
• L is C2-8alkandiyl, C2-8alkendiyl, or C2-8alkyndiyl and L is optionally substituted with a substituent selected from the group consisting of C1-4alkanyl, C3-8cycloalkanyl and phenyl;
• X is O or S;
• A2 is selected from the group consisting of phenyl, pyridinyl, pyrimidinyl, pyrazinyl, quinolinyl, and isoquinolinyl;
• R2 is independently selected from the group consisting of C1-4alkanyl, hydroxy(C1-4)alkanyl, fluorinated C1-4alkanyl, and fluoro;
• q is 1 or 2;
• A3 is selected from the group consisting of phenyl, pyridinyl, and pyrimidinyl;
• R3 is independently selected from the group consisting of hydroxy, fluoro, chloro, C1-4alkanyl, hydroxy(C1-4)alkanyl, C1-4alkanyloxy optionally substituted with amino, C1-4alkanylamino, or C1-4dialkanylamino, fluorinated alkanyloxy, fluorinated alkanyl, amino, C1-4alkanylamino, C1-4dialkanylamino, C3-8cycloalkanylamino, cyano, aminosulfonyl, C1-4alkanylsuIfonylamino, C1-4alkanyloxycarbonyl, C1-4alkanyloxycarbonylamino, aminocarbonyl, C1-4alkanylaminocarbonyl, C1-4alkanylcarbonylamino, diC1-4alkanylaminocarbonyl, and formyl, and wherein C1-4alkanyl in any of the foregoing C1-4alkanylamino and C1-4dialkanylamino containing substituent of R3 is optionally substituted with hydroxy;
• R4 is hydrogen or C1-4alkyl, and
• enantiomers, diastereomers, tautomers, solvates, and pharmaceutically acceptable salts thereof.

A compound of Formula 1 wherein:

• A1 is phenyl or thienyl;
• R1 is independently C1-4alkanyl or fluorinated C1-4alkanyl;
• p is 1;
• L is C2-4alkandiyl or C2-4alkendiyl, and L is optionally substituted with a substituent selected from the group consisting of C1-4alkanyl, C3-8cycloalkanyl and phenyl;
• X is O;
• A2 is selected from the group consisting of phenyl, pyridinyl, and isoquinolinyl;
• R2 is independently selected from the group consisting of methyl, hydroxymethyl, and fluoro;
• q is 0, 1, or 2;
• A3 is 4-phenyl, 3-phenyl, 2-pyridin-4-yl, 2-pyridin-2-yl, 3-pyridin-4-yl, 2-pyridin-3-yl, 4-pyridin-4-yl, 4-pyridin-3-yl, 4-pyridin-2-yl, 4-pyrimidin-5-yl or3-pyrimidin-2-yl when A2 is phenyl;
• and when A2 is isoquinolin-5-yl, A3 is 8-pyridin-4-yl or 8-phenyl;
• and when A2 is pyridin-3-yl, A3 is 6-phenyl, 6-pyridin-3-yl, 6-pyridin-2-yl, or 6-pyridin-4-yl;
• R3 is independently selected from the group consisting of hydroxy, fluoro, methyl, hydroxymethyl, C1-3alkanyloxy optionally substituted with amino, methylamino, or dimethylamino, trifluoromethoxy, trifluoromethyl, methylsulfonylamino, t-butoxycarbonylamino, aminocarbonyl, and methylcarbonylamino;
• r is 1;
• R4 is hydrogen, and
• enantiomers, diastereomers, tautomers, solvates, and pharmaceutically acceptable salts thereof.

A compound of Formula Ia:

• wherein:
• A1 is phenyl substituted at the 4-position with R1, or thiophen-2-yl substituted at the 5-position with R1;
• R1 is independently t-butyl or trifluoromethyl,
• L is —CH2CH2— or —CH═CH—;
• A2 is selected from the group consisting of phenyl, pyridin-3-yl, and isoquinolin-5-yl optionally substituted with R2;
• R2 is independently selected from the group consisting of hydrogen, methyl, hydroxymethyl, and fluoro;
• q is 0, 1, or 2;
• A3 is 4-phenyl, 3-phenyl, 2-pyridin-2-yl, 4-pyridin-4-yl, 4-pyridin-3-yl, 4-pyridin-2-yl, 4-pyrimidin-5-yl or 3-pyrimidin-2-yl when A2 is phenyl;
• and when A2 is isoquinolin-5-yl, A3 is 8-pyridin-4-yl or 8-phenyl;
• and when A2 is pyridin-3-yl, A3 is 6-phenyl, 6-pyridin-3-yl, 6-pyridin-2-yl, or 6-pyridin-4-yl;
• R3 is independently selected from the group consisting of hydroxy, fluoro, methyl, hydroxymethyl, 2-aminoethoxy, methylsulfonylamino, and methylcarbonylamino, and
• enantiomers, diastereomers, tautomers, solvates, and pharmaceutically acceptable salts thereof.

A compound of Formula Ia:

• wherein:
• A1 is phenyl substituted at the 4-position with R1, or thiophen-2-yl substituted at the 5-position with R1;
• R1 is independently t-butyl, trifluoromethyl, trifluoromethylsulfonyl, or trifluoromethylthio;
• L is —CH2CH2— or —CH═CH—;
• A2 is selected from the group consisting of phenyl, pyridin-3-yl, and isoquinolin-5-yl optionally substituted with R2;
• R2 is independently selected from the group consisting of methyl, hydroxymethyl, trifluoromethyl, and fluoro;
• q is 0, 1, or 2;
• A3 is 4-phenyl, 3-phenyl, 2-pyridin-2-yl, 4-pyridin-4-yl, 4-pyridin-3-yl, 4-pyridin-2-yl, 4-pyrimidin-5-yl, 3-pyrimidin-2-yl or 4-imidazol-1-yl when A2 is phenyl;
• and when A2 is isoquinolin-5-yl, A3 is 8-pyridin-4-yl or 8-phenyl;
• and when A2 is pyridin-3-yl, A3 is 6-phenyl, 6-pyridin-3-yl, 6-pyridin-2-yl, 6-pyridin-4-yl, or 6-imidazol-1-yl;
• R3 is independently selected from the group consisting of hydroxy, fluoro, chloro, methyl, hydroxymethyl, 2-aminoethoxy, methylsulfonylamino, and methylcarbonylamino,
• provided that a compound of Formula 1 is other than a compound wherein p is 1, R1 is 4-trifluoromethylsulfonyl, A1 is phenyl, L is trans —CH═CH—, X is O, A2 is pyridin-3-yl, q is 1, R2 is 5-methyl, A3 is imidazol-1-yl, r is 2, R3 is 4,5-dichloro, and R4 is hydrogens
• and
• enantiomers, diastereomers, tautomers, solvates, and pharmaceutically acceptable salts thereof.

A compound of Formula Ia

• selected from the group consisting of:
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0;
• R2 is absent;
• A3 is 2-phenyl, r is 1, and R3 is 4-hydroxy;
• a compound of Formula (Ia) wherein R1 is4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 3-phenyl, r is 1, and R3 is 4-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 4-hydroxy;
• a compound of Formula (Ia) wherein R1 is4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 2-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 3-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 2-phenyl, r is 1, and R3 is 2-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 3-phenyl, r is 1, and R3 is 2-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 2-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-nitro;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-trifluoromethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-methylcarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-chloro;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-fluoro;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-methylcarbonylamino;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-amino;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 2-phenyl, r is 1, and R3 is 3-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 2-phenyl, r is 1, and R3 is 4-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 3-phenyl, r is 1, and R3 is 3-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 3-phenyl, r is 1, and R3 is 4-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L-is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 4-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-cyano;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-trifluoromethoxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-methoxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-methyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-methoxycarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-carboxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is trans —CH═CH—, A2 is phenyl, q is 0, R2 is absent, A3 is 3-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 3-phenyl, r is 1, and R3 is 3-dimethylaminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is trans —CH═CH—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is trans —CH═CH—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-dimethylaminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 3-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 3-phenyl, r is 1, and R3 is 3-dimethylaminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-dimethylaminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-methylsulfonylamino;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-t-butoxycarbonylamino;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-t-butoxycarbonylaminomethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-aminomethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-ureido;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-(2-amino-ethoxy);
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-(2-hydroxy-ethylamino);
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is trans —CH═CH—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 2-methyl, A3 is 4-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-methyl, A3 is 4-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 2-fluoro, A3 is 4-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-fluoro, A3 is 4-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 2-methyl, A3 is 4-phenyl, r is 1, and R3 is 3-methylcarbonylamino;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-methyl, A3 is 4-phenyl, r is 1, and R3 is 3-methylcarbonylamino;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 2-fluoro, A3 is 4-phenyl, r is 1, and R3 is 3-methylcarbonylamino;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-fluoro, A3 is 4-phenyl, r is 1, and R3 is 3-methylcarbonylamino;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 2-methyl, A3 is 4-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-methyl, A3 is 4-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 2-fluoro, A3 is 4-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-fluoro, A3 is 4-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 5-t-butyl, A1 is thiophen-2-yl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 5-t-butyl, A1 is thiophen-2-yl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-methylcarbonylamino;
• a compound of Formula (Ia) wherein R, is 5-t-butyl, A1 is thiophen-2-yl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 2-carboxy, A3 is 4-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 2-carboxy, A3 is 4-phenyl, r is 1, and R3 is 3-methylaminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 2-carboxy, A3 is 4-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 2-hydroxymethyl, A3 is 4-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 2-hydroxymethyl, A3 is 4-phenyl, r is 1, and R3 is 3-methylcarbonylamino;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 2-hydroxymethyl, A3 is 4-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-carboxy, A3 is 4-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-carboxy, A3 is 4-phenyl, r is 1, and R3 is 3-methylcarbonylamino;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-carboxy, A3 is 4-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-methylcarbonylamino;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 2-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 4-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 4-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is naphthalen-1-yl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-methylcarbonylamino;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is naphthalen-1-yl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is naphthalen-1-yl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is naphthalen-1-yl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-methylcarbonylamino;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is naphthalen-1-yl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 2, R2 is 3,5-dimethyl, A3 is 4-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 2, R2 is 3,5-dimethyl, A3 is 4-phenyl, r is 1, and R3 is 4-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 2, R2 is 3,5-dimethyl, A3 is 4-phenyl, r is 1, and R3 is 4-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 2, R2 is 3,5-difluoro, A3 is 4-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 2, R2 is 3,5-difluoro, A3 is 4-phenyl, r is 1, and R3 is 4-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 2, R2 is 3,5-difluoro, A3 is 4-phenyl, r is 1, and R3 is 4-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-hydroxymethyl, A3 is 4-phenyl, r is 1, and R3 is 2-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-hydroxymethyl, A3 is 4-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-hydroxymethyl, A3 is 4-phenyl, r is 1, and R3 is 4-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-hydroxymethyl, A3 is 4-phenyl, r is 1, and R3 is 3-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-hydroxymethyl, A3 is 4-phenyl, r is 1, and R3 is 4-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-methyl, A3 is 4-phenyl, r is 1, and R3 is 2-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-methyl, A3 is 4-phenyl, r is 1, and R3 is 4-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-methyl, A3 is 4-phenyl, r is 1, and R3 is 4-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-fluoro, A3 is 4-phenyl, r is 1, and R3 is 2-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-fluoro, A3 is 4-phenyl, r is 1, and R3 is 4-hydroxy
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-fluoro, A3 is 4-phenyl, r is 1, and R3 is 4-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 2-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 3-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 2-pyridin-3-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 3-pyridin-3-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-pyridin-3-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 2-pyridin-2-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 3-pyridin-2-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-pyridin-2-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-pyrimidin-2-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-pyrimidin-5-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 3-pyridin-2-yl, r is 1, and R3 is 6-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-pyridin-2-yl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 3-pyrimidin-2-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R, is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 3-pyrimidin-5-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 3-pyridin-2-yl, r is 1, and R3 is 6-methoxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 3-pyridin-3-yl, r is 1, and R3 is 6-methoxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-pyridin-2-yl, r is 1, and R3 is 6-methoxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-pyridin-3-yl, r is 1, and R3 is 6-methoxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-1 H-indol-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-1H-indol-6-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-2-yl, q is 0, R2 is absent, A3 is 5-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-2-yl, q is 0, R2 is absent, A3 is 5-phenyl, r is 1, and R3 is 3-methylcarbonylamino;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-2-yl, q is 0, R2 is absent, A3 is 6-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is-0, R2 is absent, A3 is 6-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 0, R2 is absent, A3 is 6-phenyl, r is 1, and R3 is 3-methylcarbonylamino;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 0, R2 is absent, A3 is 6-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyrimidin-2-yl, q is 0, R2 is absent, A3 is 5-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyrazin-2-yl, q is 0, R2 is absent, A3 is 5-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 0, R2 is absent, A3 is 6-phenyl, r is 1, and R3 is 2-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 0, R2 is absent, A3 is 6-phenyl, r is 1, and R3 is 4-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 0, R2 is absent, A3 is 6-phenyl, r is 1, and R3 is 3-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 0, R2 is absent, A3 is 6-phenyl, r is 1, and R3 is 4-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 0, R2 is absent, A3 is 6-pyridin-3-yl, r is 0, and R3 absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 0, R2 is absent, A3 is 6-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is thiophen-2-yl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 2-carboxy, A3 is 4-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 2-hydroxymethyl, A3 is 4-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-carboxy, A3 is 4-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-pyridin-3-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 0, R2 is absent, A3 is 6-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 0, R2 is absent, A3 is 6-phenyl, r is 1, and R3 is 3-methylcarbonylamino;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 0, R2 is absent, A3 is 6-phenyl, r is 1, and R3 is 2-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 0, R2 is absent, A3 is 6-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 0, R2 is absent, A3 is 6-phenyl, r is 1, and R3 is 4-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 0, R2 is absent, A3 is 6-phenyl, r is 1, and R3 is 3-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 0, R2 is absent, A3 is 6-phenyl, r is 1, and R3 is 4-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 0, R2 is absent, A3 is 6-pyridin-3-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 0, R2 is absent, A3 is 6-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is naphthalen-1-yl, q is 0, R2 is absent, A3 is 4-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is isoquinolin-5-yl, q is 0, R2 is absent, A3 is 8-phenyl, r is 1, and R3 is 3-methylcarbonylamino;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is isoquinolin-5-yl, q is 0, R2 is absent, A3 is 8-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is isoquinolin-5-yl, q is 0, R2 is absent, A3 is 8-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is naphthalen- -yl, q is 0, R2 is absent, A3 is 4-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is isoquinolin-5-yl, q is 0, R2 is absent, A3 is 8-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is-phenyl, L is —(CH2)2—, A2 is isoquinolin-5-yl, q is 0, R2 is absent, A3 is 8-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-methyl, A3 is 6-phenyl, r is 1, and R3 is 2-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-methyl, A3 is 6-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-methyl, A3 is 6-phenyl, r is 1, and R3 is 4-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-methyl, A3 is 6-phenyl, r is 1, and R3 is 4-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-methyl, A3 is 6-pyridin-3-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-methyl, A3 is 6-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 2, R2 is 3,5-difluoro, A3 is 4-pyridin-3-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 2, R2 is 3,5-dimethyl, A3 is 4-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 2, R2 is 3,5-difluoro, A3 is 4-pyridin-3-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 2, R2 is 3,5-difluoro, A3 is 4-pyridin-4-yl, r is 0, and R3 is absent,
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-hydroxymethyl, A3 is 4-pyridin-3-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-hydroxymethyl, A3 is 4-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-methyl, A3 is 4-pyridin-2-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-fluoro, A3 is 4-pyridin-2-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 2, R2 is 3,5-dimethyl, A3 is 4-pyridin-2-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 2, R2 is 3,5-difluoro, A3 is 4-pyridin-2-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 0, R2 is absent, A3 is 6-pyridin-2-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-methyl, A3 is 6-pyridin-2-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyrazin-2-yl, q is 0, R2 is absent, A3 is 5-pyridin-2-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-methyl, A3 is 4-pyridin-3-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-methyl, A3 is 4-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-fluoro, A3 is 4-pyridin-3-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-fluoro, A3 is 4-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyrazin-2-yl, q is 0, R2 is absent, A3 is 5-phenyl, r is 1, and R3 is 2-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyrazin-2-yl, q is 0, R2 is absent, A3 is 5-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyrazin-2-yl, q is 0, R2 is absent, A3 is 5-phenyl, r is 1, and R3 is 4-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyrazin-2-yl, q is 0, R2 is absent, A3 is 5-phenyl, r is 1, and R3 is 4-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyrazin-2-yl, q is 0, R2 is absent, A3 is 5-pyridin-3-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyrazin-2-yl, q is 0, R2 is absent, A3 is 5-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-imidazol-2-yl, r is 1, and R3 is 1-methyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-imidazol-4-yl, r is 1, and R3 is 1-methyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-imidazol-5-yl, r is 1, and R3 is 1-methyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-imidazol-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-oxazol-5-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-(4,5-dihydro-oxazol-5-yl), r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is ′—(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-thiazol-4-yl, r is 1, and R3 is 2-methyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-pyrazol-1-yl, r is 2, and R3 is 3,5-dimethyl
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-thiadiazol-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-(1,2,4-triazol-1-yl), r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-1 H-tetrazol-5-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-imidazol-3-yl, r is 2, and R3 is 4,5-dichloro;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-(2,4-dihydro-pyrazol-2-yl), r is 2, and R3 is 3-oxo, 5-methyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-trifluoromethyl, A3 is 6-imidazol-1-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-methyl, A3 is 6-imidazol-1-yl, r is 2, and R3 is 4,5-dichloro;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-imidazol-1-yl, r is 1, and R3 is 4-methyl;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethylsulphonyl, A1 is phenyl, L is trans —CH═CH—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-imidazol-1-yl, r is 1, and R3 is 4-methyl;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-phenyl, and r is 1, R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-imidazol-1-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethylthio, A1 is phenyl, L is trans —CH═CH—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-imidazol-1-yl, r is 1, and R3 is 4-methyl;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethylsulphonyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-imidazol-1-yl, r is 1, and R3 is 4-methyl;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-trifluoromethyl, A3 is 6-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-imidazol-1-yl, r is 2, and R3 is 4,5-dichloro;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-imidazol-1-yl, r is 2, and R3 is 4,5-dichloro;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-trifluoromethyl, A3 is 6-phenyl, r is 1, and R3 is 2-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-methyl, A3 is 6-imidazol-1-yl, and r is 0, R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-methyl, A3 is 6-imidazol-1-yl, r is 2, and R3 is 4,5-dichloro;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-methyl, A3 is 6-phenyl, r is 1, and R3 is 3-methylcarbonylamino;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethylsulphonyl, A1 is phenyl, L is trans —CH═CH—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-imidazol-1-yl, r is 2, and R3 is 4,5-dichloro;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-imidazol-1-yl, r is 2, and R3 is 4,5-dichloro;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethylthio, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-imidazol-1-yl, r is 1, and R3 is 4-methyl;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-pyridin-4-yl, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-trifluoromethyl, A3 is 6-phenyl, r is 1, and R3 is 4-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethylsulphanyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-imidazol-1-yl, r is 1, and. R3 is 4-methyl;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-phenyl, r is 1, and R3 is 4-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-trifluoromethyl, A3 is 6-imidazol-1-yl, r is 2, and R3 is 4,5-dichloro;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-trifluoromethyl, A3 is 6-phenyl, r is 1, and R3 is 4-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-methyl, A3 is 6-imidazol-1-yl, r is 1, and R3 is 4-methyl;
• a compound of Formula (Ia) wherein 1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-imidazol-1-yl, r is 1, and R3 is 4-chloro;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethylthio, A1 is phenyl, L is trans —CH═CH—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-imidazol-1-yl, r is 2, and R3 is 4,5-dichloro;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-phenyl, r is 1, and R3 is 4-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-chloro, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-chloro, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-imidazol-1-yl, r is 2, and R3 is 4,5-dichloro;
• a compound of Formula (Ia) wherein R1 is 4-N-cyclohexyl-N-methylamino, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-methyl, A3 is 6-imidazol-1-yl, r is 2, and R3 is 4,5-dichloro;
• a compound of Formula (Ia) wherein R1 is 5-trifluoromethyl, A1 is pyridin-2-yl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-imidazol-1-yl, r is 1, and R3 is 4-methyl;
• a compound of Formula (Ia) wherein R1 is 4-chloro, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2is 5-methyl, A3 is 6-imidazol-1-yl, r is 2, and R3 is 4,5-dichloro;
• a compound of Formula (Ia) wherein R1 is 5-trifluoromethyl, A1 is pyridin-2-yl, L is trans —CH═CH—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-imidazol-1-yl, r is 2, and R3 is 4,5-dichloro;
• a compound of Formula (Ia) wherein R1 is 5-trifluoromethylsulfonyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-imidazol-1-yl, r is 2, and R3 is 4,5-dichloro;
• a compound of Formula (Ia) wherein R1 is 5-trifluoromethylsulfonyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-methyl, A3 is 6-imidazol-1-yl, r is 2, and R3 is 4,5-dichloro;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-imidazol-1-yl, r is 1, and R3 is 4-trifluoromethyl;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethylthio, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-imidazol-1-yl, r is 2, and R3 is 4,5-dichloro;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-trifluoromethyl, A3 is 6-imidazol-1-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-N-cyclohexyl-N-methylamino, A1 is phenyl, L is trans —CH═CH—, A2 is pyridin-3-yl, q is 1, R2 is 5-methyl, A3 is 6-imidazol-1-yl, r is 2, and R3 is 4,5-dichloro;
• a compound of Formula (Ia) wherein R1 is 4-chloro, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-imidazol-1-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-fluoro, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-imidazol-1-yl, r is 2, and R3 is 4,5-dichloro;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethylsulfinyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-imidazol-1-yl, r is 2, and R3 is 4,5-dichloro;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-(2-oxo-2,3-dihydro-2λ4-[1,2,3,5]oxathiadiazol-4-yl), r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-methyl, A3 is 6-phenyl, r is 1, and R3 is 3-cyano;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-methyl, A3 is 6-imidazol-1-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 5-trifluoromethyl, A1 is pyridin-2-yl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-imidazol-1-yl, and r is 2, R3 is 4,5-dichloro;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-trifluoromethyl, A3 is 6-pyridin-3-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-phenyl, r is 1, and R3 is 4-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-trifluoromethyl, A3 is 6-imidazol-1-yl, r is 2, and R3 is 4,5-dichloro;
• a compound of Formula (Ia) wherein R1 is hydrogen, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-benzoimidazol-1-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-pyridin-4-yl, r is 1, and R3 is 2-fluoro;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-trifluoromethyl, A3 is 6-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 3,4-difluoro, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-imidazol-1-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 3,4-difluoro, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-methyl, A3 is 6-imidazol-1-yl, r is 2, and R3 is 4,5-dichloro;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-pyridin-3-yl, r is 1, and R3 is 2-fluoro;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-methyl, A3 is 6-phenyl, r is 1, and R3 is 3-methoxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-methyl, A3 is 6-phenyl, r is 1, and R3 is 3-nitro;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-imidazol-1-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-imidazol-1-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-imidazol-1-yl, r is 2, and R3 is 4,5-dichloro;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-imidazol-1-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-(1,2,4-oxadiazol-3-yl), r is 1, and R3 is 5-trifluoromethyl;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-(1,2,4-oxadiazol-3-yl), r is 1, and R3 is 5-methyl;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-imidazol-1-yl, r is 1, and R3 is 2-methyl;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-imidazol-1-yl, r is 1, and R3 is 2-isopropyl;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-indol-1-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-(4,5,6,7-tetrahydro-benzoimidazol-1-yl), r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-imidazol-1-yl, r is 1, and R3 is 4-methoxycarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethylthio, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-methyl, A3 is 6-imidazol-1-yl, r is 2, and R3 is 4,5-dichloro;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethylsulfinyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-methyl, A3 is 6-imidazol-1-yl, r is 2, and R3 is 4,5-dichloro;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethylsulfinyl, A1 is phenyl, L is trans —CH═CH—, A2 is pyridin-3-yl, q is 1, R2 is 5-methyl, A3 is 6-imidazol-1-yl, r is 2, and R3 is 4,5-dichloro;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethylthio, A1 is phenyl, L is trans —CH═CH—, A2 is pyridin-3-yl, q is 1, R2 is 5-methyl, A3 is 6-imidazol-1-yl, r is 2, and R3 is 4,5-dichloro;
• a compound of Formula (Ia) wherein R1 is 5-trifluoromethyl, A1 is pyridin-2-yl, L is trans —CH═CH—, A2 is pyridin-3-yl, q is 1, R2 is 5-methyl, A3 is 6-imidazol-1-yl, r is 2, and R3 is 4,5-dichloro;
• a compound of Formula (Ia) wherein R1 is 5-trifluoromethyl, A1 is pyridin-2-yl, L is trans —CH═CH—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-imidazol-1-yl, r is 1, and R3 is 4-methyl;
• a compound of Formula (Ia) wherein R1 is 5-trifluoromethyl, A1 is pyridin-2-yl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-methyl, A3 is 6-imidazol-1-yl, r is 2, and R3 is 4,5-dichloro;
• a compound of Formula (Ia) wherein R1 is 4-fluoro, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-trifluoromethyl, A3 is 4-imidazol-1-yl, r is 0, and R3 is absent;
• and
• a compound of Formula (Ia) wherein R1 is 4-fluoro, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-methyl, A3 is 6-imidazol-1-yl, r is 2, and R3 is 4,5-dichloro.

A compound of Formula Ia

• selected from the group consisting of:
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0;
• R2 is absent;
• A3 is 2-phenyl, r is 1, and R3 is 4-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 3-phenyl, r is 1, and R3 is 4-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 4-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 2-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 3-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 2-phenyl, r is 1, and R3 is 2-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 3-phenyl, r is 1, and R3 is 2-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 2-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-nitro;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-trifluoromethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-methylcarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-chloro;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-fluoro;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-methylcarbonylamino;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-amino;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 2-phenyl, r is 1, and R3 is 3-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 2-phenyl, r is 1, and R3 is 4-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 3-phenyl, r is 1, and R3 is 3-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 3-phenyl, r is 1, and R3 is 4-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2is absent, A3 is 4-phenyl, r is 1, and R3 is 4-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-cyano;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2is absent, A3 is 4-phenyl, r is 1, and R3 is 3-trifluoromethoxy,
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2is absent, A3 is 4-phenyl, r is 1, and R3 is 3-methoxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2is absent, A3 is 4-phenyl, r is 1, and R3 is 3-methyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2is absent, A3 is 4-phenyl, r is 1, and R3 is 3-methoxycarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2is absent, A3 is 4-phenyl, r is 1, and R3 is 3-carboxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2is absent, A3 is 4-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is trans —CH═CH—, A2 is phenyl, q is 0, R2is absent, A3 is 3-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 3-phenyl, r is 1, and R3 is 3-dimethylaminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is trans —CH═CH—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is trans —CH═CH—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-dimethylaminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 3-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 3-phenyl, r is 1, and R3 is 3-dimethylaminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-dimethylaminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-methylsulfonylamino;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-t-butoxycarbonylamino;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-t-butoxycarbonylaminomethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-aminomethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-ureido;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-(2-amino-ethoxy);
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-(2-hydroxy-ethylamino);
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is trans —CH═CH—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 2-methyl, A3 is 4-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-methyl, A3 is 4-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 2-fluoro, A3 is 4-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-fluoro, A3 is 4-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 2-methyl, A3 is 4-phenyl, r is 1, and R3 is 3-methylcarbonylamino;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-methyl, A3 is 4-phenyl, r is 1, and R3 is 3-methylcarbonylamino;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 2-fluoro, A3 is 4-phenyl, r is 1, and R3 is 3-methylcarbonylamino;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-fluoro, A3 is 4-phenyl, r is 1, and R3 is 3-methylcarbonylamino;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 2-methyl, A3 is 4-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-methyl, A3 is 4-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 2-fluoro, A3 is 4-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-fluoro, A3 is 4-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 5-t-butyl, A1 is thiophen-2-yl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 5-t-butyl, A1 is thiophen-2-yl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-methylcarbonylamino;
• a compound of Formula (Ia) wherein R1 is 5-t-butyl, A1 is thiophen-2-yl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 2-carboxy, A3 is 4-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 2-carboxy, A3 is 4-phenyl, r is 1, and R3 is 3-methylaminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 2-carboxy, A3 is 4-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 2-hydroxymethyl, A3 is 4-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 2-hydroxymethyl, A3 is 4-phenyl, r is 1, and R3 is 3-methylcarbonylamino;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 2-hydroxymethyl, A3 is 4-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-carboxy, A3 is 4-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compourid of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-carboxy, A3 is 4-phenyl, r is 1, and R3 is 3-methylcarbonylamino;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-carboxy, A3 is 4-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-methylcarbonylamino;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 2-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 4-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 4-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is naphthalen-1-yl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-methylcarbonylamino;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is naphthalen-1-yl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is naphthalen-1-yl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is naphthalen-1-yl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-methylcarbonylamino;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is naphthalen-1-yl, q is 0, R2 is absent, A3 is 4-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 2, R2 is 3,5-dimethyl, A3 is 4-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 2, R2 is 3,5-dimethyl, A3 is 4-phenyl, r is 1, and R3 is 4-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 2, R2 is 3,5-dimethyl, A3 is 4-phenyl, r is 1, and R3 is 4-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 2, R2 is 3,5-difluoro, A3 is 4-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 2, R2 is 3,5-difluoro, A3 is 4-phenyl, r is 1, and R3 is 4-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 2, R2 is 3,5-difluoro, A3 is. 4-phenyl, r is 1, and R3 is 4-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-hydroxymethyl, A3 is 4-phenyl, r is 1, and R3 is 2-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-hydroxymethyl, A3 is 4-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-hydroxymethyl, A3 is 4-phenyl, r is 1, and R3 is 4-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-hydroxymethyl, A3 is 4-phenyl, r is 1, and R3 is 3-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-hydroxymethyl, A3 is 4-phenyl, r is 1, and R3 is 4-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-methyl, A3 is 4-phenyl, r is 1, and R3 is 2-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-methyl, A3 is 4-phenyl, r is 1, and R3 is 4-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-methyl, A3 is 4-phenyl, r is 1, and R3 is 4-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-fluoro, A3 is 4-phenyl, r is 1, and R3 is 2-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-fluoro, A3 is 4-phenyi, r is 1, and R3 is 4-hydroxy
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-fluoro, A3 is 4-phenyl, r is 1, and R3 is 4-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 2-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 3-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 2-pyridin-3-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 3-pyridin-3-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-pyridin-3-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 2-pyridin-2-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 3-pyridin-2-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-pyridin-2-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1. is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-pyrimidin-2-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-pyrimidin-5-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 3-pyridin-2-yl, r is 1, and R3 is 6-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-pyridin-2-yl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 3-pyrimidin-2-yl, r is 0, and R3 is absent;
• a compound-of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 3-pyrimidin-5-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 3-pyridin-2-yl, r is 1, and R3 is 6-methoxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 3-pyridin-3-yl, r is 1, and R3 is 6-methoxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-pyridin-2-yl, r is 1, and R3 is 6-methoxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-pyridin-3-yl, r is 1, and R3 is 6-methoxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-1 H-indol-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-1 H-indol-6-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-2-yl, q is 0, R2 is absent, A3 is 5-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-2-yl, q is 0, R2 is absent, A3 is 5-phenyl, r is 1, and R3 is 3-methylcarbonylamino;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-2-yl, q is 0, R2 is absent, A3 is 6-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 0, R2 is absent, A3 is 6-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 0, R2 is absent, A3 is 6-phenyl, r is 1, and R3 is 3-methylcarbonylamino;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 0, R2 is absent, A3 is 6-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is-(CH2)2—, A2 is pyrimidin-2-yl, q is 0, R2 is absent, A3 is 5-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyrazin-2-yl, q is 0, R2 is absent, A3 is 5-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 isfphenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 0, R2 is absent, A3 is 6-phenyl, r is 1, and R3 is 2-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 0, R2 is absent, A3 is 6-phenyl, r is 1, and R3 is 4-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 0, R2 is absent, A3 is 6-phenyl, r is 1, and R3 is 3-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 0, R2 is absent, A3 is 6-phenyl, r is 1, and R3 is 4-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 0, R2 is absent, A3 is 6-pyridin-3-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 0, R2 is absent, A3 is 6-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is thiophen-2-yl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-pyridin-4-yl, r is 0, and absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 2-carboxy, A3 is 4-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 2-hydroxymethyl, A3 is 4-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-carboxy, A3 is 4-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-pyridin-3-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 0, R2 is absent, A3 is 6-phenyl, r is 1, and R3 is 3-aminocarbonyl;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 0, R2 is absent, A3 is 6-phenyl, r is 1, and R3 is 3-methylcarbonylamino;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 0, R2 is absent, A3 is 6-phenyl, r is 1, and R3 is 2-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 0, R2 is absent, A3 is 6-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 0, R2 is absent, A3 is 6-phenyl, r is 1, and R3 is 4-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 0, R2 is absent, A3 is 6-phenyl, r is 1, and R3 is 3-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 0, R2 is absent, A3 is 6-phenyl, r is 1, and R3 is 4-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 0, R2 is absent, A3 is 6-pyridin-3-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 0, R2 is absent, A3 is 6-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is naphthalen-1-yl, q is 0, R2 is absent, A3 is 4-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is isoquinolin-5-yl, q is 0, R2 is absent, A3 is 8-phenyl, r is 1, and R3 is 3-methylcarbonylamino;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is isoquinolin-5-yl, q is 0, R2 is absent, A3 is 8-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is isoquinolin-5-yl, q is 0, R2 is absent, A3 is 8-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is naphthalen- -yl, q is 0, R2 is absent, A3 is 4-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is isoquinolin-5-yl, q is 0, R2 is absent, A3 is 8-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-trifluoromethyl, A1 is phenyl, L is —(CH2)2—, A2 is isoquinolin-5-yl, q is 0, R2 is absent, A3 is 8-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-methyl, A3 is 6-phenyl, r is 1, and R3 is 2-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-methyl, A3 is 6-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-methyl, A3 is 6-phenyl, r is 1, and R3 is 4-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-methyl, A3 is 6-phenyl, r is 1, and R3 is 4-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl,. L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-methyl, A3 is 6-pyridin-3-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-methyl, A3 is 6-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 2, R2 is 3,5-difluoro, A3 is 4-pyridin-3-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 2, R2 is 3,5-dimethyl, A3 is 4-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 2, R2 is 3,5-difluoro, A3 is 4-pyridin-3-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 2, R2 is 3,5-difluoro, A3 is 4-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-hydroxymethyl, A3 is 4-pyridin-3-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-hydroxymethyl, A3 is 4-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-methyl, A3 is 4-pyridin-2-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-fluoro, A3 is 4-pyridin-2-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 2, R2 is 3,5-dimethyl, A3 is 4-pyridin-2-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 2, R2 is 3,5-difluoro, A3 is 4-pyridin-2-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 0, R2 is absent, A3 is 6-pyridin-2-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyridin-3-yl, q is 1, R2 is 5-methyl, A3 is 6-pyridin-2-yl, r is 0, and R3 absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyrazin-2-yl, q is 0, R2 is absent, A3 is 5-pyridin-2-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-methyl, A3 is 4-pyridin-3-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-methyl, A3 is 4-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-fluoro, A3 is 4-pyridin-3-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 1, R2 is 3-fluoro, A3 is 4-pyridin-4-yl, r is 0, and R3 is
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyrazin-2-yl, q is 0, R2 is absent, A3 is 5-phenyl, r is 1, and R3 is 2-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyrazin-2-yl, q is 0, R2 is absent, A3 is 5-phenyl, r is 1, and R3 is 3-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyrazin-2-yl, q is 0, R2 is absent, A3 is 5-phenyl, r is 1, and R3 is 4-hydroxy;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyrazin-2-yl, q is 0, R2 is absent, A3 is 5-phenyl, r is 1, and R3 is 4-hydroxymethyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyrazin-2-yl, q is 0, R2 is absent, A3 is 5-pyridin-3-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is pyrazin-2-yl, q is 0, R2 is absent, A3 is 5-pyridin-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-imidazol-2-yl, r is 1, and R3 is 1-methyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-imidazol-4-yl, r is 1, and R3 is 1-methyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-imidazol-5-yl, r is 1, and R3 is 1-methyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-imidazol-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-oxazol-5-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-(4,5-dihydro-oxazol-5-yl), r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is ′—-(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-thiazol-4-yl, r is 1, and R3 is 2-methyl;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-pyrazol-1-yl, r is 2, and R3 is 3,5-dimethyl
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-thiadiazol-4-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-(1 ,2,4-triazol-1-yl), r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-1H-tetrazol-5-yl, r is 0, and R3 is absent;
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-imidazol-3-yl, r is 2, and R3 is 4,5-dichloro;
• and
• a compound of Formula (Ia) wherein R1 is 4-t-butyl, A1 is phenyl, L is —(CH2)2—, A2 is phenyl, q is 0, R2 is absent, A3 is 4-(2,4-dihydro-pyrazol-2-yl), r is 2, and R3 is 3-oxo, 5-methyl.