Substituted chroman derivatives

A compound of formula (I)

• wherein
• X is N;
• Y is NR2CH2, CH2NR2, NR2CO, CONR2, NR2SO2 or NR2CONR2 wherein R2 is H or C1-C6 alkyl;
• R1 is H, C1-C6 alkyl or C3-C6 cycloalkyl;
• R3 is C1-C6 alkyl, C3-C6 cycloalkyl or (CH2)n-aryl,
• wherein aryl is a heteroaromatic ring containing one or two heteroatoms selected from N, O and S and which may be mono- or di-substituted with R4 and/or R5;
• wherein R4 is selected from the group consisting of
• a) H,
• b) C1-C6 alkyl,
• c) C3-C6 cycloalkyl,
• d) halogen,
• e) CN,
• f) CF3,
• g) OH,
• h) C1-C6 alkoxy,
• i) NR6R7,
• j) OCF3,
• k) SO3CH3,
• l) SO3CF3,
• m) SO2NR6R7,
• n) phenyl,
• o) phenyl-C1-C6 alkyl,
• p) phenoxy,
• q) C1-C6 alkylphenyl,
• r) an optionally substituted heterocyclic ring containing one or two heteroatoms selected from N, O, S, SO and SO2 wherein the substituent(s) is(are) selected from C1-C6 alkyl, C3-C6 cycloalkyl, phenyl-C1-C6 alkyl, (CH2)m OR9 wherein m is 2-6 and R9 is H, C1-C6 alkyl, C3-C6 cycloalkyl or phenyl-C1-C6 alkyl, and COR8,
• s) an optionally substituted heteroaromatic ring containing one or two heteroatoms selected from N, O and S wherein the ring substituent(s) is(are) selected from the group consisting of C1-C6 alkyl, C3-C6 cycloalkyl and phenyl-C1-C6 alkyl, and
• t) COR8;
• wherein R6 is H, C1-C6 alkyl or C3-C6 cycloalkyl;
• R7 is H, C1-C6 alkyl or C3-C6 cycloalkyl;
• and
• R8 is C1-C6 alkyl, C3-C6 cycloalkyl, CF3, NR6R7 or phenyl;
• R5 is H, OH, TF3, OCF3, halogen, C1-C6 alkyl or C1-C6 alkoxy;
• and n is 0-4;
• wherein the compound is an (R)-enantiomer, an (S)-enantiomer, or a racemate in the form of a free base or a pharmaceutically acceptable salt or solvate thereof.