Back to results
US 2006/0223820 A1Published application
Crystalline aripiprazole salts and processes for preparation and purification thereof
AssigneeChemagis Ltd.
InventorsMichael Brand, Moti Shookrun, Irina Gribun, Itai Adin, Carmen Iustain, Oded Arad, Joseph Kaspi
Life of this patent
Estimating the term…
Abstract
Provided are novel crystalline carboxylic acid salts of aripiprazole, methods of using such salts, and processes for producing such salts.
Claims34
A crystalline carboxylic acid salt of 7-(4-(4-(2,3-dichlorophenyl)-1-piperazinyl)-butoxy)-3,4-dihydro-2(1H)-quinolinone (aripiprazole).
A process for preparing a salt of aripiprazole, the process comprising:
- dissolving aripiprazole in an organic solvent, optionally by heating a suspension of aripiprazole in the solvent;
- adding a solution of an acid in an organic solvent;
- allowing the mixture to cool sufficiently to produce crystals of the aripiprazole salt;
- isolating the crystals;
- and
- optionally washing and drying the crystals, wherein the drying is optionally performed under reduced pressure.
3 more elements
Dependencies are inferred from the claim text.