Therapeutic agents comprising an anti-angiogenic agent in combination with an src-inhibitor and their therapeutic use
OwnerJon Curwen, Stephen Wedgeinventors
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Abstract
The invention relates to the use of an anti-angiogenic agent in combination with an inhibitor of the Src family of non-receptor tyrosine kinases in the manufacture of a medicament for use in the substantially normotensive treatment in a warm-blooded mammal such as a human being of a disease state associated with angiogenesis, the Src kinase inhibitor being administered in an amount effective to counteract substantially the hypertension induced by the anti-angiogenic agent.
Claims12
The use of an anti-angiogenic agent in combination with an inhibitor of the Src family of non-receptor tyrosine kinases in the manufacture of a medicament for use in the substantially normotensive treatment in a warm-blooded mammal such as a human being of a disease state associated with angiogenesis, the Src kinase inhibitor being administered in an amount effective to counteract substantially the hypertension induced by the anti-angiogenic agent.
A synergistic combination product comprising an anti-angiogenic agent and a Src kinase inhibitor for use simultaneously, sequentially or separately in the production of an anti-cancer effect in a warm-blooded animal such as a human being.
A blood pressure effect sparing combination product comprising an anti-angiogenic agent and a Src kinase inhibitor for use simultaneously, sequentially or separately in the production of an anti-cancer effect in a warm-blooded animal such as a human being.
A combination product comprising an anti-angiogenic agent and a Src kinase inhibitor for use simultaneously, sequentially or separately in the production of a substantially normotensive anti-cancer effect in a warm-blooded mammal such as a human being.
Dependencies are inferred from the claim text.