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US 2006/0223805 A1Published application
Arylalklcarbamate derivatives, preparation method thereof and use of same in therapeutics
AssigneeSanofi-Aventis
InventorsAhmed Abouabdellah, Antonio Almario Garcia
Life of this patent
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Abstract
The invention relates to a compound having general formula (I): Wherein n, A, R1, R2, and R3 are as defined herein. The invention also relates to methods of preparation of compound of formula (I) as well as its use in therapeutics.
Claims21
A compound of the formula (I):
- in which
- n represents an integer between 1 and 6;
- A is a group X;
- X represents a C1-2-alkylene group optionally substituted with one or more C1-12-alkyl, C3-7-cycloalkyl or C3-7-cycloalkyl-C1-6-alkylene groups;
- R1 represents a hydrogen atom, a halogen atom, or a hydroxyl, cyano, nitro, C1-3-alkyl, C1-3-alkoxy, C1-3-thioalkyl, C1-3-fluoroalkyl, C1-3-fluoroalkoxy or C1-3-fluorothioalkyl group;
- R2 represents a hydrogen atom, a halogen atom, or a cyano, nitro, hydroxyl, C1-3-alkyl, C1-3-alkoxy, C1-3-thioalkyl, C1-3-fluoroalkyl, C1-3-fluoroalkoxy or C1-3-fluorothioalkyl group;
- or a group chosen from a phenyl, naphthalenyl, biphenyl, phenylethylenyl, naphthylethylenyl, pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, triazinyl, indanyl, indenyl, quinolinyl, isoquinolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, cinnolinyl, thienyl, furyl, pyrrolyl, imidazolyl, pyrazolyl, oxazolyl, thiazolyl, isoxazolyl, isothiazolyl, thiadiazolyl, oxadiazolyl, triazolyl, benzothienyl, benzofuryl, dibenzofuryl, benzimidazolyl, benzotriazolyl, indolyl, isoindolyl, indazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, dihydroindolyl, pyrrolopyridinyl, furopyridinyl, thienopyridinyl, imidazopyridinyl, oxazolopyridinyl, thiazolopyridinyl, pyrazolopyridinyl, isoxazolopyridinyl, isothiazolopyridinyl, tetrahydroquinolinyl, tetrahydroisoquinolinyl, phenyloxy, phenylthio, phenylsulfonyl, benzoyl, phenylmethoxy, phenylethoxy, phenylpropoxy, naphthalenyloxy, naphthalenylmethoxy, naphthalenylethoxy, naphthalenylpropoxy, quinolinoxy and isoquinolinoxy, and optionally substituted with one or more substituents chosen from a halogen atom, and the following groups:
- hydroxyl, cyano, nitro, C1-4-alkyl, C1-4-alkoxy, C1-4-thioalkyl, C1-3-fluoroalkyl, C1-3-fluoroalkoxy, C1-3-fluorothioalkyl, phenyloxy, benzyloxy, piperidyl, pyrrolidinyl, morpholinyl, NH2, NHR6, NR6R7, NHCOR6, COR6, CO2R6, SO2R6, —O—(C1-3-alkylene)-O—, 4-piperazinyl optionally substituted with a C1-3-alkyl or with a benzyl;
- R3 represents either a 2,2,2-trifluoroethyl group, or a phenyl group optionally substituted with one or more halogen atoms or cyano, nitro, C1-3-alkyl, C1-3-alkoxy, trifluoromethyl or trifluoromethoxy groups, and
- R6 and R7 represent, independently of one another, a C1-3-alkyl group or a phenyl;
- with the proviso that:
- when R3 represents a 2,2,2-trifluoroethyl group and the group -[A]n- represents a —CH2— group, then R1 is other than a hydrogen atom or a methoxy group;
- and
- when R3 represents an optionally substituted phenyl group and the group -[A]n- represents a —CH2—, —CH2CH2—, —CH(CH3)— or —CH(CH3)—CH2— group, then R1 is other than a hydrogen or chlorine atom or a methyl or methoxy group and R2 is other than a hydrogen atom;
- and
- wherein said compound is in the form of a base, or an addition salt with an acid, or a hydrate or a solvate.
13 more elements
Dependencies are inferred from the claim text.