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AssigneeAventis Pharmaceuticals Products Inc.
InventorsJune Kaplow, Thomas Haws, Marie Rosier, Patrice Denefle
Estimating the term…
The present invention is directed to nuclear factor κB (NFκB)-inducing factor polypeptides (NFIF polypeptides) which are capable of inducing NFκB. The present invention includes within its scope NFIF polypeptides, including NFIF-14b and NFIF-7a, DNA, including cDNA, encoding these polypeptides, and expression vectors capable of expressing NFIF polypeptides. Also included are methods and compositions for increasing NFκB induction in a patient, methods and compositions for lowering NFκB induction in a patient, methods for inhibiting inflammation, and methods for manufacutre of a medicament intended for the treatment and/or prevention of an NFκB-regulated inflammatory response. In addition, methods for determining whether a test compound inhibits or enhances the activity of NFIF polypeptides are provided.
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An isolated nucleic acid encoding NFIF-7a polypeptide comprising the amino acid sequence shown in FIG. 2 (SEQ ID NO:
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An isolated NFIF-7a polypeptide which induces NFκB and comprises an amino acid sequence as shown in FIG. 2 (SEQ ID NO:
A method of increasing expression of NFκB in a patient comprising introducing into the body of said patient a composition that induces NFκB.
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A composition for lowering the expression of the NFIF gene in a patient wherein said composition is an antisense nucleic acid or a ribozyme that cuts RNA encoding an NFIF polypeptide.
A composition for lowering the activity of an NFIF polypeptide in a patient comprising a neutralizing antibody that binds to an NFIF polypeptide and lowers its activity.
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A method for evaluating whether a test compound is effective in inhibiting the activity of NFIF-14b or NFIF-7a based on the expression of an NFκB-regulated reporter gene comprising:
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A method for identifying whether a test compound can enhance the activity of NFIF-14b or NFIF-7a based on the expression of an NFκB-regulated reporter gene comprising:
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A method of inhibiting expression of NFκB-dependent genes comprising administration to a patient of a composition that inhibits the activity of NFIF-14b or NFIF-7a.
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A method of inhibiting inflammation comprising administration of a composition that inhibits the activity of NFIF-14b or NFIF-7a.
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Use of an isolated NFIF polypeptide comprising an amino acid sequence of FIG. 1 (SEQ ID NO:
Use of a nucleic acid encoding an NFIF polypeptide comprising an amino acid sequence of FIG. 1 (SEQ ID NO:
Dependencies are inferred from the claim text.