Vaccines using nucleic acid-lipid complexes
AssigneeNational Jewish Medical and Research Center
InventorsSteven Dow, Robyn Elmslie, Jurgen Karl Schwarze, Erwin Gelfand
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Abstract
This invention relates to a vaccine and a method for immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in a mammal. The method is particularly effective for protecting a mammal from a disease including cancer, a disease associated with allergic inflammation, an infectious disease, or a condition associated with a deleterious activity of a self-antigen. Also disclosed are therapeutic compositions useful in such a method.
Claims36
A vaccine comprising:
- a. at least one immunogen for vaccinating a mammal;
- b. a liposome;
- and
- c. an isolated nucleic acid molecule that does not express said immunogen of (a);
- wherein said immunogen and said isolated nucleic acid molecule are complexed to or within said liposome.
A method to elicit a systemic, immunogen-specific immune response in a mammal, comprising administering to said mammal a vaccine comprising:
- a. at least one immunogen for vaccinating a mammal;
- b. a liposome;
- and
- c. an isolated nucleic acid molecule that does not express said immunogen of (a);
- wherein said immunogen and said isolated nucleic acid molecule are complexed to or within said liposome.
Dependencies are inferred from the claim text.