Classes of compounds that interact with gpcrs

A method of inhibiting or effecting the activity of a GPCR which comprises contacting a GPCR with a compound of general formula 1, or a pharmaceutically acceptable salt thereof

• Wherein the ring may be of any configuration;
• Z is selected from the group consisting of:
• sulphur, oxygen, or NRA wherein RA is selected from the set defined for R1 to R5 or C1 to C15 acyl, C4 to C15 arylacyl or C4 to C15 heteroarylacyl, with the proviso that both R1 and RA are not hydrogen,
• X is selected from the group consisting of:
• oxygen or NRA providing that at least one X of General Formula I is NRA,
• R1 to R5 are independently selected from the group consisting of:
• H, C1 to C12 alkyl, C1 to C12 alkenyl, C1 to C12 alkynyl, C1 to C12 heteroalkyl, C4 to C15 aryl, C4 to C15 heteroaryl, C4 to C15 arylalkyl or C4 to C15 heteroarylalkyl substituent,
• wherein, when X is NRA, both RA and the corresponding R1 to R5 are not hydrogen.