Compositions and methods for treatment of cancer

A pyrroloquinolinyl-pyrrolidine-2,5-dione compound of formula IVa, IVb, Va, or Vb, or pharmaceutically acceptable salts thereof:

• where:
• R1, R2 and R3 are independently selected from the group consisting of hydrogen, F, Cl, Br, I, —NR5R6, —C1-C6) alkyl, —(C1-C6) substituted alkyl, —(C3-C9) cycloalkyl, —C3-C9) substituted cycloalkyl, —O—(C1-C6) alkyl, —O—(C1-C6) substituted alkyl, —(C3-C9) cycloalkyl, and —O—(C3-C9) substituted cycloalkyl, aryl, heteroaryl, heterocyclyl;
• R4 is independently selected from the group consisting of hydrogen, —(C1-C6) alkyl, —CH2R7;
• R5, R6 are independently selected from the group consisting of hydrogen, and —(C1-C6) alkyl;
• R7 is independently selected from the group consisting of —O—P(═O)(OH)2, —O—P(═O)(—OH)(—O—(C1-C6) alkyl), —O—P(═O)(—O—(C1-C6) alkyl)2, —O—P(═O)(—OH) (—O—(CH2)-phenyl), —O—P(═O)(—O—(CH2)-phenyl)2, a carboxylic acid group, an amino carboxylic acid group and a peptide;
• Q is selected from the group consisting of aryl, heteroaryl, —O-aryl, —S-aryl, —O-heteroaryl, and —S-heteroaryl;
• X is selected from the group consisting of —(CH2)—, —(NR8)-, S, and O;
• R8 is independently selected from the group consisting of hydrogen, —(C1-C6) alkyl, —(C1-C6) substituted alkyl, —(C3-C9) cycloalkyl, —(C3-C9) substituted cycloalkyl, and —O—(C1-C6) alkyl, —C(═O)—O—(C1-C6) alkyl and —C(═O)—O—(C1-C6) substituted alkyl;
• Y is selected from the group consisting of —(CH2)— or a bond;
• wherein said aryl, heteroaryl, —O-aryl, —S-aryl, —O-heteroaryl, and —S-heteroaryl groups may be substituted with one or more substituents independently selected from the group consisting of F, Cl, Br, I, —NR5R6, —(C1-C6) alkyl, —(C1-C6) substituted alkyl, —(C3-C9) cycloalkyl, —(C3-C9) substituted cycloalkyl, —O—(C1-C6) alkyl, —O—(C1-C6) substituted alkyl, —O—(C3-C9) cycloalkyl, —O—(C3-C9) substituted cycloalkyl, -aryl, -aryl-C1-C6) alkyl, -aryl-O—(C1-C6) alkyl, —O-aryl, —O—(C1-C4) alkyl-aryl, heteroaryl, heterocyclyl, —O—(C1-C4) alkyl-heterocycle, and —S(═O)2)—(C1-C6) alkyl;
• and
• m is 1 or 2.