Endothelial cell specifically binding peptides
OwnerGene Liau, Steingrimur Stefansson +1inventors
InventorsGene Liau, Steingrimur Stefansson, Joseph Su
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Abstract
The present invention relates to peptides that specifically bind to endothelial cells. The peptides can be incorporated into gene delivery vector particles and can also direct therapeutic agents, including proteins such as growth factors and cytokines as well as small molecules. The vector particles, peptides, or small molecules can be used for the treatment of cancer and cardiovascular diseases such as ischemic heart disease, peripheral limb disease, vein graft stenosis and restenosis.
Claims35
A peptide selected from the group consisting of:
- (a) CPDLHHHMC (SEQ ID NO:1), CLGQHAFTC (SEQ ID NO:2), CSSNTAPHC (SEQ ID NO:3), CHVLPNGNC (SEQ ID NO:4), CKPQYPSLC (SEQ ID NO:5), CQTARTPAC (SEQ ID NO:6), CNQSQPKHC (SEQ ID NO:7), CTPSKISVC (SEQ ID NO:8), CVSPGPRLC (SEQ ID NO:9), CYALSGVPC (SEQ ID NO:10), CKHPPQPFC (SEQ ID NO:11), CHQSKPLLC (SEQ ID NO:12), CPGPFSNWC (SEQ ID NO:13), CPHKTHLPC (SEQ ID NO:14), CVFPLSHYC (SEQ ID NO:15), CNMIAPSSC (SEQ ID NO:16), CTLGMQFQC (SEQ ID NO:17), CTNPTGMLC (SEQ ID NO:18), CSNMAPRSC (SEQ ID NO:19), CSMAPNMSC (SEQ ID NO:20), CSDLTMEAC (SEQ ID NO:21), CPWPYKYSC (SEQ ID NO:22), CFGGNFHRC (SEQ ID NO:23), CLTTSQQTC (SEQ ID NO:24), CTANSGSFC (SEQ ID NO:25), CQEPLDESC (SEQ ID NO:26), CQMSMFARC (SEQ ID NO:27), CPLTPKAYC (SEQ ID NO:28), CNNSHTALC (SEQ ID NO:29), CLSSDITLC (SEQ ID NO:30), CLTHGPKYC (SEQ ID NO:31), CLGKDLRTC (SEQ ID NO:32), CAPKTHPLC (SEQ ID NO:33), CPTGLMKYC (SEQ ID NO:34), CTWKAPLQC (SEQ ID NO:35), CSHILGPSC (SEQ ID NO:36), CLSTSQYSC (SEQ ID NO:37) or CXXPTPPXC (SEQ ID NO:44);
- (b) amino acids 1-8 of a peptide according to (a);
- (c) amino acids 2-9 of a peptide according to (a);
- and
- (d) amino acids 2-8 of a peptide according to (a).
A pharmaceutical composition comprising the conjugate of any oie of claim&-and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.