Peptide inhibitors of toxins derived from ll-37
AssigneeAcademisch Ziekenhuis Leiden
InventorsJohannes Grote, Jan Drijfhout
Life of this patent
Estimating the term…
Abstract
The present invention relates to a group of peptidic compounds which have affinity for toxins and especially for bacterial toxins, such as lipopolysaccharide or lipoteichoic acid. These compounds can inhibit or neutralize the toxins. In addition, the present invention relates to the use of these compounds as therapeutic or diagnostic agents.
Claims19
A peptidic compound with affinity to bacterial and fungal toxins, and especially to lipopolysaccharide (LPS) or lipoteichoic acid (LTA) comprising an amino acid sequence X1KEFX2RIVX3RIKX4FLRX5LVX6, wherein
- X1 represents the N-terminal part;
- X2 is K or E;
- X3 is Q or E;
- X4 is D or R;
- X5 is N or E;
- X6 represents the C-terminal part;
- wherein one or more of the amino acids of the core sequence are optionally derivatized, wherein the N-terminal part is acetylated and/or the C-terminal part is amidated and/or the amino acid sequence differs from the native amino acid sequence X1KEFKRIVQRIKDFLRNLVX6.
A nucleic acid sequence encoding a peptidic compound comprising the amino acid sequence KEFX2RIVX3RIKX4FLRX5LV, wherein
- X2 is K or E;
- X3 is Q or E;
- X4 is D or R;
- and
- X5 is N or E, nor being KEFKRIVQRIKDFLRNLV.
Dependencies are inferred from the claim text.