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US 2006/0223754 A1Published application
Human TSLP polynucleotides
AssigneeImmunex Corporation
InventorsJohn Sims, Stewart Lyman, Hilary McKenna, Allison Armstrong
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Abstract
The invention is directed to purified and isolated novel TSLP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.
Claims7
An isolated nucleic acid molecule selected from the group consisting of:
- (a) the DNA sequence of SEQ ID NO:1;
- (b) an isolated nucleic acid molecule encoding a polypeptide having an amino acid sequence comprising the sequence of SEQ ID NO:2;
- (c) an isolated nucleic acid molecule that hybridizes to either strand of a denatured, double-stranded DNA comprising the nucleic acid sequence of (a) or (b) under conditions of moderate stringency in 50% formamide and 6×SSC, at 42° C.with washing conditions of 60° C., 0.5×SSC, 0.1% SDS;
- (d) an isolated nucleic acid molecule encoding a polypeptide having an amino acid sequence that is at least 80% identical to the sequence of SEQ ID NO:
- 2, wherein the polypeptide is capable of stimulating lymphopoiesis.
- (e) an isolated nucleic acid molecule comprising a nucleotide sequence that is at least 80% identical to SEQ ID NO:
- 1.
4 more elements
Dependencies are inferred from the claim text.