Stress based removal of nonspecific binding from surfaces
OwnerGrant Meyer, Jose Manuel Moran-Mirabal +1inventors
InventorsGrant Meyer, Jose Manuel Moran-Mirabal, Harold Craighead
Life of this patent
Estimating the term…
Abstract
A biological material sensing surface is exposed to a biological material that is selectively bound to a selected sensing portion of the sensing surface. The sensing surface is then subjected to shear stress oscillations to selectively remove nonspecifically bound material. The shear stress may be provided by an ultrasound resonator operating at a power sufficient to selectively remove nonspecifically bound biological material, such as protein from non-sensing areas of the sensing surface, which may be micropatterned array.
Claims20
A method comprising:
- exposing a biological material sensing surface to biological material;
- and
- subjecting the surface to shear stress to selectively remove nonspecifically bound biological material.
A method comprising:
- exposing a biological material sensing surface to biological material, which binds at sensing portions of the sensing surface;
- and
- subjecting the sensing surface to ultrasonic waves to selectively remove nonspecifically bound biological material.
A method comprising:
- exposing a protein array to proteins;
- subjecting the protein array to shear stress to selectively remove nonspecifically bound protein;
- and
- detecting florescent intensity from the array.
A method comprising:
- creating a sensing area on a quartz crystal resonator;
- exposing the sensing area to labeled biological material;
- subjecting the sensing area to shear stress by oscillating the quartz crystal resonator to selectively remove nonspecifically bound biological material;
- and
- detecting florescent intensity from the sensing area.
Dependencies are inferred from the claim text.