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US 2006/0223194 A1Published application
Methods of screening for post-translationally modified proteins
OwnerViorica Lopez-Avila, Carol Schembriinventors
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Abstract
The invention provides methods of analyzing a sample. In general, the methods involve: a) depositing sub-fractions of a multi-dimensionally fractionated sample into wells of a multi-well substrate; b) contacting each of the deposited sub-fractions with an array to produce a set of sub-fraction-contacted arrays; and c) interrogating the sub-fraction-contacted arrays to identify a sub-fraction containing a post-translationally modified analyte. Also provided are systems and kits for performing the subject methods.
Claims28
A method of sample analysis, comprising:
- depositing sub-fractions of a multi-dimensionally fractionated sample into wells of a multi-well substrate;
- contacting each of said deposited sub-fractions with an array to produce a plurality of sub-fraction-contacted arrays;
- and
- interrogating said sub-fraction-contacted arrays to identify a sub-fraction containing a post-translationally modified analyte.
1 more element
A system for sample analysis, comprising:
- a multi-dimensional sample fractionation system for producing sub-fractions of a sample;
- a multi-well substrate for receiving said sub-fractions;
- a plurality of arrays;
- an array reader;
- and
- a system for assessing analyte mass.
3 more elements
A kit comprising:
- a plurality of arrays of capture agents that bind to post-translationally modified analytes.
Dependencies are inferred from the claim text.